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Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15
Aaron M. Ring
, Jian Xin Lin
, Dan Feng
, Suman Mitra
, Mathias Rickert
, Gregory R. Bowman
, Vijay S. Pande
, Peng Li
, Ignacio Moraga
, Rosanne Spolski
, Engin Özkan
, Warren J. Leonard
, K. Christopher Garcia
Department of Biochemistry & Molecular Biophysics
Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)
Institute of Clinical and Translational Sciences (ICTS)
Research output
:
Contribution to journal
›
Article
›
peer-review
195
Scopus citations
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Keyphrases
Structural Insights
100%
Mechanistic Insight
100%
Interleukin-2
100%
Interleukin-15 (IL-15)
100%
Functional Dichotomy
100%
IL Interleukin
100%
Soluble interleukin-2 Receptor (sIL-2R)
88%
Lymphocytes
11%
Receptor Binding
11%
Receptor Affinity
11%
Immunotherapeutics
11%
Receptor Subunits
11%
Allostery
11%
Similar Signals
11%
Immunological Function
11%
Signal Properties
11%
Trans-signaling
11%
Binding Chemistry
11%
Quaternary Complex
11%
Immunology and Microbiology
Interleukin 2
100%
Interleukin 15
100%
Cytokine
11%
Receptor Binding
11%
Allosterism
11%
Receptor Affinity
11%
Lymphocyte
11%