Mechanisms responsible for enhanced stroke volume after exercise training in coronary heart disease

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

High intensity endurance exercise training increases maximal attainable O2 uptake (VO2(max)) and stroke volume (SV) in patients with ischaemic heart disease. To determine the mechanisms responsible for enhanced SV after training, 18 patients, 51 ± 3 years (mean ± SE) were studied. Patients completed 12 months of endurance exercise with a peak intensity of 89.7 ± 2% of attainable VO2(max). Attainable VO2(max) increased from 23 ± 1 to 32 ± 2 ml/kg/min (P < 0.0001). Left ventricular function was assessed using radionuclide ventriculography. To control for afterload, haemodynamic variables were evaluated at comparable mean blood pressure (mBP). SV was increased after training both at rest (77 ± 3 vs 81.5 ± 5 ml; P < 0.025) and during exercise (78 ± 6 vs 93 ± 6 ml; P < 0.025) at comparable mBP. Before training, ejection fraction decreased during exercise (59 ± 3 vs 55 ± 3%, P < 0.005) but increased after training from the resting level (59 ± 3 vs 63 ± 3%, P < 0.025). Left ventricular end diastolic volume during exercise did not change. Thus, the results suggest that enhanced SV during exercise is, in part, due to improved left ventricular function after exercise training.

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalEuropean heart journal
Volume8
Issue numberSUPPL. G
StatePublished - Dec 1 1987

Fingerprint Dive into the research topics of 'Mechanisms responsible for enhanced stroke volume after exercise training in coronary heart disease'. Together they form a unique fingerprint.

  • Cite this