Mechanisms of transcriptional regulation by Rb-E2F segregate by biological pathway

Arthur P. Young, Rakesh Nagarajan, Gregory D. Longmore

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

The E2F family of transcription factors are critical regulators of the cell cycle and have also been implicated in apoptosis, development, DNA damage checkpoints, and differentiation. Retinoblastoma (Rb) proteins interact with E2F to regulate transcription, and several mechanisms have been proposed for Rb-E2F transcriptional regulation. We designed microarray-based experiments to characterize the relative contributions of each mechanism, and unexpectedly, we found that distinct functional gene groups show preference for one mechanism over the others. We propose that such a distribution may provide signaling specificity to enable regulatory proteins to turn on or off entire pathways that determine cell fate.

Original languageEnglish
Pages (from-to)7209-7217
Number of pages9
JournalOncogene
Volume22
Issue number46
DOIs
StatePublished - Oct 16 2003

Keywords

  • Biological pathways
  • E2F
  • Rb

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