Mechanisms of sympathoadrenal failure and hypoglycemia in diabetes

Philip E. Cryer

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations

Abstract

A reduced sympathoadrenal response, induced by recent antecedent hypoglycemia, is the key feature of hypoglycemia-associated autonomic failure (HAAF) and, thus, the pathogenesis of iatrogenic hypoglycemia in diabetes. Understanding of the mechanism(s) of that reduced response awaits new insight into its basic molecular, cellular, organ, and whole-body physiology and pathophysiology in experimental models. In this issue of the JCI, McCrimmon and colleagues report that application of urocortin I (a corticotrophin-releasing factor receptor-2 agonist) to the ventromedial hypothalamus reduces the glucose counterregulatory response to hypoglycemia in rats (see the related article beginning on page 1723). Thus, hypothalamic urocortin I release during antecedent hypoglycemia is, among other possibilities, a potential mechanism of HAAF.

Original languageEnglish
Pages (from-to)1470-1473
Number of pages4
JournalJournal of Clinical Investigation
Volume116
Issue number6
DOIs
StatePublished - Jun 1 2006

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