TY - JOUR
T1 - Mechanisms of restriction of viral neuroinvasion at the blood-brain barrier
AU - Miner, Jonathan J.
AU - Diamond, Michael S.
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - The blood-brain barrier (BBB) consists of highly specialized cells including brain microvascular endothelial cells, astrocytes, microglia, pericytes, and neurons, which act in concert to restrict the entry of pathogens, immune cells, and soluble molecules into the central nervous system (CNS). If pathogens manage to cross the BBB and establish infection within the CNS, the BBB can open in a regulated manner to allow leukocyte transmigration into the CNS so that microbes, infected cells, and debris can be cleared. This review highlights how different inflammatory cytokines or signaling pathways disrupt or enhance BBB integrity in a way that regulates entry of neurotropic viruses into the CNS.
AB - The blood-brain barrier (BBB) consists of highly specialized cells including brain microvascular endothelial cells, astrocytes, microglia, pericytes, and neurons, which act in concert to restrict the entry of pathogens, immune cells, and soluble molecules into the central nervous system (CNS). If pathogens manage to cross the BBB and establish infection within the CNS, the BBB can open in a regulated manner to allow leukocyte transmigration into the CNS so that microbes, infected cells, and debris can be cleared. This review highlights how different inflammatory cytokines or signaling pathways disrupt or enhance BBB integrity in a way that regulates entry of neurotropic viruses into the CNS.
UR - http://www.scopus.com/inward/record.url?scp=84946949853&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2015.10.008
DO - 10.1016/j.coi.2015.10.008
M3 - Review article
C2 - 26590675
AN - SCOPUS:84946949853
SN - 0952-7915
VL - 38
SP - 18
EP - 23
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
ER -