TY - JOUR
T1 - Mechanisms of Renal Fibrosis
AU - Humphreys, Benjamin D.
N1 - Publisher Copyright:
© 2018 by Annual Reviews. All rights reserved.
PY - 2018/2/10
Y1 - 2018/2/10
N2 - Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging and in chronic kidney disease (CKD), regardless of cause. CKD and renal fibrosis affect half of adults above age 70 and 10% of the world's population. Although no targeted therapy yet exists to slow renal fibrosis, a number of important recent advances have clarified the cellular and molecular mechanisms underlying the disease. In this review, I highlight these advances with a focus on cells and pathways that may be amenable to therapeutic targeting. I discuss pathologic changes regulating interstitial myofibroblast activation, including profibrotic and proinflammatory paracrine signals secreted by epithelial cells after either acute or chronic injury. I conclude by highlighting novel therapeutic targets and approaches with particular promise for development of new treatments for patients with fibrotic kidney disease.
AB - Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging and in chronic kidney disease (CKD), regardless of cause. CKD and renal fibrosis affect half of adults above age 70 and 10% of the world's population. Although no targeted therapy yet exists to slow renal fibrosis, a number of important recent advances have clarified the cellular and molecular mechanisms underlying the disease. In this review, I highlight these advances with a focus on cells and pathways that may be amenable to therapeutic targeting. I discuss pathologic changes regulating interstitial myofibroblast activation, including profibrotic and proinflammatory paracrine signals secreted by epithelial cells after either acute or chronic injury. I conclude by highlighting novel therapeutic targets and approaches with particular promise for development of new treatments for patients with fibrotic kidney disease.
KW - Dedifferentiation
KW - Fibrosis
KW - Mesenchymal stem cell
KW - Myofibroblast
KW - Pericyte
UR - http://www.scopus.com/inward/record.url?scp=85041909001&partnerID=8YFLogxK
U2 - 10.1146/annurev-physiol-022516-034227
DO - 10.1146/annurev-physiol-022516-034227
M3 - Review article
C2 - 29068765
AN - SCOPUS:85041909001
SN - 0066-4278
VL - 80
SP - 309
EP - 326
JO - Annual review of physiology
JF - Annual review of physiology
ER -