Mechanisms of red blood cell transfusion-related immunomodulation

for the Pediatric Critical Care Blood Research Network (Blood Net)

doi:10.1111/trf.14488

Mechanisms of red blood cell transfusion-related immunomodulation

for the Pediatric Critical Care Blood Research Network (Blood Net)

Division of Critical Care Medicine

Research output: Contribution to journal › Review article › peer-review

98 Scopus citations

Abstract

Red blood cell (RBC) transfusion is common in critically ill, postsurgical, and posttrauma patients in whom both systemic inflammation and immune suppression are associated with adverse outcomes. RBC products contain a multitude of immunomodulatory mediators that interact with and alter immune cell function. These interactions can lead to both proinflammatory and immunosuppressive effects. Defining clinical outcomes related to immunomodulatory effects of RBCs in transfused patients remains a challenge, likely due to complex interactions between individual blood product characteristics and patient-specific risk factors. Unpacking these complexities requires an in-depth understanding of the mechanisms of immunomodulatory effects of RBC products. In this review, we outline and classify potential mediators of RBC transfusion-related immunomodulation and provide suggestions for future research directions.

Original language	English
Pages (from-to)	804-815
Number of pages	12
Journal	Transfusion
Volume	58
Issue number	3
DOIs	https://doi.org/10.1111/trf.14488
State	Published - Mar 2018

Access to Document

10.1111/trf.14488

Cite this

@article{8d663b71d36f4b44a9731962e2ad38ab,

title = "Mechanisms of red blood cell transfusion-related immunomodulation",

abstract = "Red blood cell (RBC) transfusion is common in critically ill, postsurgical, and posttrauma patients in whom both systemic inflammation and immune suppression are associated with adverse outcomes. RBC products contain a multitude of immunomodulatory mediators that interact with and alter immune cell function. These interactions can lead to both proinflammatory and immunosuppressive effects. Defining clinical outcomes related to immunomodulatory effects of RBCs in transfused patients remains a challenge, likely due to complex interactions between individual blood product characteristics and patient-specific risk factors. Unpacking these complexities requires an in-depth understanding of the mechanisms of immunomodulatory effects of RBC products. In this review, we outline and classify potential mediators of RBC transfusion-related immunomodulation and provide suggestions for future research directions.",

author = "{for the Pediatric Critical Care Blood Research Network (Blood Net)} and Remy, {Kenneth E.} and Hall, {Mark W.} and Jill Cholette and Juffermans, {Nicole P.} and Kathleen Nicol and Allan Doctor and Neil Blumberg and Spinella, {Philip C.} and Norris, {Philip J.} and Dahmer, {Mary K.} and Muszynski, {Jennifer A.}",

note = "Publisher Copyright: {\textcopyright} 2018 AABB",

year = "2018",

month = mar,

doi = "10.1111/trf.14488",

language = "English",

volume = "58",

pages = "804--815",

journal = "Transfusion",

issn = "0041-1132",

number = "3",

}

TY - JOUR

T1 - Mechanisms of red blood cell transfusion-related immunomodulation

AU - for the Pediatric Critical Care Blood Research Network (Blood Net)

AU - Remy, Kenneth E.

AU - Hall, Mark W.

AU - Cholette, Jill

AU - Juffermans, Nicole P.

AU - Nicol, Kathleen

AU - Doctor, Allan

AU - Blumberg, Neil

AU - Spinella, Philip C.

AU - Norris, Philip J.

AU - Dahmer, Mary K.

AU - Muszynski, Jennifer A.

PY - 2018/3

Y1 - 2018/3

N2 - Red blood cell (RBC) transfusion is common in critically ill, postsurgical, and posttrauma patients in whom both systemic inflammation and immune suppression are associated with adverse outcomes. RBC products contain a multitude of immunomodulatory mediators that interact with and alter immune cell function. These interactions can lead to both proinflammatory and immunosuppressive effects. Defining clinical outcomes related to immunomodulatory effects of RBCs in transfused patients remains a challenge, likely due to complex interactions between individual blood product characteristics and patient-specific risk factors. Unpacking these complexities requires an in-depth understanding of the mechanisms of immunomodulatory effects of RBC products. In this review, we outline and classify potential mediators of RBC transfusion-related immunomodulation and provide suggestions for future research directions.

AB - Red blood cell (RBC) transfusion is common in critically ill, postsurgical, and posttrauma patients in whom both systemic inflammation and immune suppression are associated with adverse outcomes. RBC products contain a multitude of immunomodulatory mediators that interact with and alter immune cell function. These interactions can lead to both proinflammatory and immunosuppressive effects. Defining clinical outcomes related to immunomodulatory effects of RBCs in transfused patients remains a challenge, likely due to complex interactions between individual blood product characteristics and patient-specific risk factors. Unpacking these complexities requires an in-depth understanding of the mechanisms of immunomodulatory effects of RBC products. In this review, we outline and classify potential mediators of RBC transfusion-related immunomodulation and provide suggestions for future research directions.

UR - http://www.scopus.com/inward/record.url?scp=85041169750&partnerID=8YFLogxK

U2 - 10.1111/trf.14488

DO - 10.1111/trf.14488

M3 - Review article

C2 - 29383722

AN - SCOPUS:85041169750

SN - 0041-1132

VL - 58

SP - 804

EP - 815

JO - Transfusion

JF - Transfusion

IS - 3

ER -

Mechanisms of red blood cell transfusion-related immunomodulation

Abstract

Access to Document

Other files and links

Fingerprint

Cite this