Abstract
Defects in apoptotic pathways can promote cancer development and cause cancers to become resistant to chemotherapy. The cell adhesion and signaling molecule PECAM-1 has been shown to potently suppress apoptosis in a variety of cellular systems. PECAM-1 expression has been reported on a variety of human malignancies - especially hematopoietic and vascular cell cancers - but the significance of this expression has not been fully explored. The ability of PECAM-1 to inhibit apoptosis makes it an attractive candidate as a molecule that may promote cancer development and/or confer resistance to chemotherapeutic treatment. The exact mechanisms by which PECAM-1 mediates its cytoprotection have not been fully defined, but its anti-apoptotic effects have been shown to require both homophilic binding and intracellular signaling via its immunoreceptor tyrosine-based inhibitory motif (ITIM) domains. In this review, we will discuss the data regarding PECAM-1's anti-apoptotic effects and ways in which this cytoprotection may be clinically relevant to the development and/or treatment of hematologic malignancies that express this vascular cell-specific surface molecule.
Original language | English |
---|---|
Pages (from-to) | 1409-1421 |
Number of pages | 13 |
Journal | Leukemia and Lymphoma |
Volume | 46 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2005 |
Keywords
- Apoptosis
- Cancer
- Leukemia
- PECAM-1
- SHP-2