TY - JOUR
T1 - Mechanisms of Non-segmented Negative Sense RNA Viral Antagonism of Host RIG-I-Like Receptors
AU - Leung, Daisy W.
N1 - Publisher Copyright:
© 2019
PY - 2019/10/4
Y1 - 2019/10/4
N2 - The pattern recognition receptors RIG-I-like receptors (RLRs) are critical molecules for cytosolic viral recognition and for subsequent activation of type I interferon production. The interferon signaling pathway plays a key role in viral detection and generating antiviral responses. Among the many pathogens, the non-segmented negative sense RNA viruses target the RLR pathway using a variety of mechanisms. Here, I review the current state of knowledge on the molecular mechanisms that allow non-segmented negative sense RNA virus recognition and antagonism of RLRs.
AB - The pattern recognition receptors RIG-I-like receptors (RLRs) are critical molecules for cytosolic viral recognition and for subsequent activation of type I interferon production. The interferon signaling pathway plays a key role in viral detection and generating antiviral responses. Among the many pathogens, the non-segmented negative sense RNA viruses target the RLR pathway using a variety of mechanisms. Here, I review the current state of knowledge on the molecular mechanisms that allow non-segmented negative sense RNA virus recognition and antagonism of RLRs.
KW - IFN antagonism
KW - RIG-I-like receptors
KW - host-viral interactions
KW - non-segmented negative sense RNA viruses
UR - http://www.scopus.com/inward/record.url?scp=85067657341&partnerID=8YFLogxK
U2 - 10.1016/j.jmb.2019.06.002
DO - 10.1016/j.jmb.2019.06.002
M3 - Review article
C2 - 31202887
AN - SCOPUS:85067657341
SN - 0022-2836
VL - 431
SP - 4281
EP - 4289
JO - Journal of Molecular Biology
JF - Journal of Molecular Biology
IS - 21
ER -