Mechanisms of Non-segmented Negative Sense RNA Viral Antagonism of Host RIG-I-Like Receptors

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Abstract

The pattern recognition receptors RIG-I-like receptors (RLRs) are critical molecules for cytosolic viral recognition and for subsequent activation of type I interferon production. The interferon signaling pathway plays a key role in viral detection and generating antiviral responses. Among the many pathogens, the non-segmented negative sense RNA viruses target the RLR pathway using a variety of mechanisms. Here, I review the current state of knowledge on the molecular mechanisms that allow non-segmented negative sense RNA virus recognition and antagonism of RLRs.

Original languageEnglish
Pages (from-to)4281-4289
Number of pages9
JournalJournal of Molecular Biology
Volume431
Issue number21
DOIs
StatePublished - Oct 4 2019

Keywords

  • IFN antagonism
  • RIG-I-like receptors
  • host-viral interactions
  • non-segmented negative sense RNA viruses

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