TY - JOUR
T1 - Mechanisms of Non-segmented Negative Sense RNA Viral Antagonism of Host RIG-I-Like Receptors
AU - Leung, Daisy W.
N1 - Funding Information:
Research work in the Leung laboratory is supported by the National Institutes of Health (R01A107056, P01AI120943, R01AI40758) and by the Children's Discovery Institute of Washington University and St. Louis Children's Hospital (PD-II-2018-702).
Funding Information:
Research work in the Leung laboratory is supported by the National Institutes of Health ( R01A107056 , P01AI120943 , R01AI40758 ) and by the Children’s Discovery Institute of Washington University and St. Louis Children’s Hospital ( PD-II-2018-702 ).
Publisher Copyright:
© 2019
PY - 2019/10/4
Y1 - 2019/10/4
N2 - The pattern recognition receptors RIG-I-like receptors (RLRs) are critical molecules for cytosolic viral recognition and for subsequent activation of type I interferon production. The interferon signaling pathway plays a key role in viral detection and generating antiviral responses. Among the many pathogens, the non-segmented negative sense RNA viruses target the RLR pathway using a variety of mechanisms. Here, I review the current state of knowledge on the molecular mechanisms that allow non-segmented negative sense RNA virus recognition and antagonism of RLRs.
AB - The pattern recognition receptors RIG-I-like receptors (RLRs) are critical molecules for cytosolic viral recognition and for subsequent activation of type I interferon production. The interferon signaling pathway plays a key role in viral detection and generating antiviral responses. Among the many pathogens, the non-segmented negative sense RNA viruses target the RLR pathway using a variety of mechanisms. Here, I review the current state of knowledge on the molecular mechanisms that allow non-segmented negative sense RNA virus recognition and antagonism of RLRs.
KW - IFN antagonism
KW - RIG-I-like receptors
KW - host-viral interactions
KW - non-segmented negative sense RNA viruses
UR - http://www.scopus.com/inward/record.url?scp=85067657341&partnerID=8YFLogxK
U2 - 10.1016/j.jmb.2019.06.002
DO - 10.1016/j.jmb.2019.06.002
M3 - Review article
C2 - 31202887
AN - SCOPUS:85067657341
VL - 431
SP - 4281
EP - 4289
JO - Journal of Molecular Biology
JF - Journal of Molecular Biology
SN - 0022-2836
IS - 21
ER -