Mechanisms of Non-segmented Negative Sense RNA Viral Antagonism of Host RIG-I-Like Receptors

Daisy W. Leung

doi:10.1016/j.jmb.2019.06.002

Mechanisms of Non-segmented Negative Sense RNA Viral Antagonism of Host RIG-I-Like Receptors

Daisy W. Leung

Research output: Contribution to journal › Review article

1 Scopus citations

Abstract

The pattern recognition receptors RIG-I-like receptors (RLRs) are critical molecules for cytosolic viral recognition and for subsequent activation of type I interferon production. The interferon signaling pathway plays a key role in viral detection and generating antiviral responses. Among the many pathogens, the non-segmented negative sense RNA viruses target the RLR pathway using a variety of mechanisms. Here, I review the current state of knowledge on the molecular mechanisms that allow non-segmented negative sense RNA virus recognition and antagonism of RLRs.

Original language	English
Pages (from-to)	4281-4289
Number of pages	9
Journal	Journal of Molecular Biology
Volume	431
Issue number	21
DOIs	https://doi.org/10.1016/j.jmb.2019.06.002
State	Published - Oct 4 2019

Keywords

IFN antagonism
RIG-I-like receptors
host-viral interactions
non-segmented negative sense RNA viruses

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10.1016/j.jmb.2019.06.002

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Leung, D. W. (2019). Mechanisms of Non-segmented Negative Sense RNA Viral Antagonism of Host RIG-I-Like Receptors. Journal of Molecular Biology, 431(21), 4281-4289. https://doi.org/10.1016/j.jmb.2019.06.002

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