Mechanisms of non-apoptotic programmed cell death in diabetes and heart failure

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Programmed cell elimination is an important pathological mediator of disease. Multiple pathways to programmed cell death have been delineated, including apoptosis, autophagy and programmed necrosis. Cross-talk between the signaling pathways mediating each process has made it difficult to define specific mechanisms of in vivo programmed cell death. For this reason, many "apoptotic" diseases may involve other death signaling pathways. Recent advances in genetic complementation using mouse knock-out models are helping to dissect apoptotic and necrotic cell death in different pathological states. The current state of research in this area is reviewed, focusing upon new findings describing the role of programmed necrosis induced by the mitochondrial permeability transition in mouse models of heart failure and diabetes.

Original languageEnglish
Pages (from-to)3442-3448
Number of pages7
JournalCell Cycle
Volume9
Issue number17
DOIs
StatePublished - Sep 1 2010

Keywords

  • Apoptosis
  • Mitochondrial permeability transition pore
  • Necrosis

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