Mechanisms of immune lysis. II. CTL-induced nuclear disintegration of the target begins within minutes of cell contact

J. H. Russell, C. B. Dobos

Research output: Contribution to journalArticlepeer-review

99 Scopus citations

Abstract

Within minutes of CTL-target interaction, the intracellular disintegration of the target cell nucleus begins. This nuclear event satisfies the ionic and temperature requirements that have been described by others as important in CTL-mediated lysis. Such nuclear disintegration does not occur in Ab+C-lysed targets. Thus the target cell nucleus appears to signal a primary event in CTL-mediated lysis that distinguishes the CTL lytic mechanism for that of Ab+C.

Original languageEnglish
Pages (from-to)1256-1261
Number of pages6
JournalJournal of Immunology
Volume125
Issue number3
StatePublished - Jan 1 1980

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