Mechanisms of immune lysis. I. Physiological distinction between target cell death mediated by cytotoxic T lymphocytes and antibody plus complement

J. H. Russell, V. R. Masakowski, C. B. Dobos

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

The pattern of progressive release of cytosolic (51Cr) and nuclear (125IUdR) labels from normal or tumor cells being lysed by cytotoxic T lymphocytes (CTL) is strikingly different from the pattern observed when similar cells are lysed by Ab + C or hypotonic shock. It is proposed that these differences reflect physiologic differences in the lytic events associated with Ab + C- and CTL-mediated cell death.

Original languageEnglish
Pages (from-to)1100-1105
Number of pages6
JournalJournal of Immunology
Volume124
Issue number3
StatePublished - Jan 1 1980

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