Mechanisms of immune lysis. I. Physiological distinction between target cell death mediated by cytotoxic T lymphocytes and antibody plus complement

The pattern of progressive release of cytosolic (⁵¹Cr) and nuclear (¹²⁵IUdR) labels from normal or tumor cells being lysed by cytotoxic T lymphocytes (CTL) is strikingly different from the pattern observed when similar cells are lysed by Ab + C or hypotonic shock. It is proposed that these differences reflect physiologic differences in the lytic events associated with Ab + C- and CTL-mediated cell death.