Mechanisms of Disordered Granulopoiesis in Congenital Neutropenia

David S. Grenda, Daniel C. Link

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Abstract

Neutrophils are critical components of the innate immune response, and persistent neutropenia is associated with a marked susceptibility to infection. There are a number of inherited clinical syndromes in which neutropenia is a prominent feature. A study of these rare disorders has provided insight into the mechanisms regulating normal neutrophil homeostasis. Tremendous progress has been made at defining the genetic basis of these disorders. Herein, progress in understanding the genetic basis and molecular mechanisms of these disorders is discussed. We have focused our discussion on inherited disorders in which neutropenia is the sole or major hematopoietic defect.

Original languageEnglish
Title of host publicationCurrent Topics in Developmental Biology
EditorsGerald Schatten
Pages133-176
Number of pages44
DOIs
StatePublished - Jul 20 2006

Publication series

NameCurrent Topics in Developmental Biology
Volume74
ISSN (Print)0070-2153

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  • Cite this

    Grenda, D. S., & Link, D. C. (2006). Mechanisms of Disordered Granulopoiesis in Congenital Neutropenia. In G. Schatten (Ed.), Current Topics in Developmental Biology (pp. 133-176). (Current Topics in Developmental Biology; Vol. 74). https://doi.org/10.1016/S0070-2153(06)74005-4