Mechanisms of disease: Cell death

Richard S. Hotchkiss; Andreas Strasser; Jonathan E. McDunn; Paul E. Swanson

doi:10.1056/NEJMra0901217

Mechanisms of disease: Cell death

Richard S. Hotchkiss, Andreas Strasser, Jonathan E. McDunn, Paul E. Swanson

Research output: Contribution to journal › Review article › peer-review

1033 Scopus citations

Abstract

This review is a primer on the three main mechanisms of cell death: apoptosis, autophagy-associated cell death, and necrosis. The authors discuss the clinical implications of each of these types of cell death and indicate where advances in our understanding have inspired new forms of therapy.

Original language	English
Pages (from-to)	1570-1583
Number of pages	14
Journal	New England Journal of Medicine
Volume	361
Issue number	16
DOIs	https://doi.org/10.1056/NEJMra0901217
State	Published - Oct 15 2009

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title = "Mechanisms of disease: Cell death",

abstract = "This review is a primer on the three main mechanisms of cell death: apoptosis, autophagy-associated cell death, and necrosis. The authors discuss the clinical implications of each of these types of cell death and indicate where advances in our understanding have inspired new forms of therapy.",

author = "Hotchkiss, {Richard S.} and Andreas Strasser and McDunn, {Jonathan E.} and Swanson, {Paul E.}",

year = "2009",

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T2 - Cell death

AU - Hotchkiss, Richard S.

AU - Strasser, Andreas

AU - McDunn, Jonathan E.

AU - Swanson, Paul E.

PY - 2009/10/15

Y1 - 2009/10/15

N2 - This review is a primer on the three main mechanisms of cell death: apoptosis, autophagy-associated cell death, and necrosis. The authors discuss the clinical implications of each of these types of cell death and indicate where advances in our understanding have inspired new forms of therapy.

AB - This review is a primer on the three main mechanisms of cell death: apoptosis, autophagy-associated cell death, and necrosis. The authors discuss the clinical implications of each of these types of cell death and indicate where advances in our understanding have inspired new forms of therapy.

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U2 - 10.1056/NEJMra0901217

DO - 10.1056/NEJMra0901217

M3 - Review article

C2 - 19828534

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VL - 361

SP - 1570

EP - 1583

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 16

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Mechanisms of disease: Cell death

Abstract

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