Mechanisms of disease: Cell death

Richard S. Hotchkiss, Andreas Strasser, Jonathan E. McDunn, Paul E. Swanson

Research output: Contribution to journalReview articlepeer-review

981 Scopus citations


This review is a primer on the three main mechanisms of cell death: apoptosis, autophagy-associated cell death, and necrosis. The authors discuss the clinical implications of each of these types of cell death and indicate where advances in our understanding have inspired new forms of therapy.

Original languageEnglish
Pages (from-to)1570-1583
Number of pages14
JournalNew England Journal of Medicine
Issue number16
StatePublished - Oct 15 2009


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