Mechanisms linking circadian clocks, sleep, and neurodegeneration

Research output: Contribution to journalReview article

196 Scopus citations

Abstract

Disruptions of normal circadian rhythms and sleep cycles are consequences of aging and can profoundly affect health. Accumulating evidence indicates that circadian and sleep disturbances, which have long been considered symptoms of many neurodegenerative conditions, may actually drive pathogenesis early in the course of these diseases. In this Review, we explore potential cellular and molecular mechanisms linking circadian dysfunction and sleep loss to neurodegenerative diseases, with a focus on Alzheimer's disease. We examine the interplay between central and peripheral circadian rhythms, circadian clock gene function, and sleep in maintaining brain homeostasis, and discuss therapeutic implications. The circadian clock and sleep can influence a number of key processes involved in neurodegeneration, suggesting that these systems might be manipulated to promote healthy brain aging.

Original languageEnglish
Pages (from-to)1004-1008
Number of pages5
JournalScience
Volume354
Issue number6315
DOIs
StatePublished - Nov 25 2016

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