Mechanisms for oxidizing low-density lipoprotein: Insights from patterns of oxidation products in the artery wall and from mouse models of atherosclerosis

Joseph P. Gaut; Jay W. Heinecke

doi:10.1016/S1050-1738(01)00101-3

Mechanisms for oxidizing low-density lipoprotein: Insights from patterns of oxidation products in the artery wall and from mouse models of atherosclerosis

Joseph P. Gaut, Jay W. Heinecke

Research output: Contribution to journal › Review article › peer-review

92 Scopus citations

Abstract

The oxidation hypothesis proposes that oxidative modification of low density lipoprotein (LDL) plays a critical role in atherogenesis. This review critically evaluates the various mechanisms proposed for LDL oxidation, focusing on insights derived from chemical analysis of human artery wall and studies of genetically engineered mice. The implications of recent clinical trials of vitamin E for the oxidation hypothesis are also briefly discussed.

Original language	English
Pages (from-to)	103-112
Number of pages	10
Journal	Trends in Cardiovascular Medicine
Volume	11
Issue number	3-4
DOIs	https://doi.org/10.1016/S1050-1738(01)00101-3
State	Published - Jan 1 2001

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10.1016/S1050-1738(01)00101-3

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title = "Mechanisms for oxidizing low-density lipoprotein: Insights from patterns of oxidation products in the artery wall and from mouse models of atherosclerosis",

abstract = "The oxidation hypothesis proposes that oxidative modification of low density lipoprotein (LDL) plays a critical role in atherogenesis. This review critically evaluates the various mechanisms proposed for LDL oxidation, focusing on insights derived from chemical analysis of human artery wall and studies of genetically engineered mice. The implications of recent clinical trials of vitamin E for the oxidation hypothesis are also briefly discussed.",

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AU - Heinecke, Jay W.

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N2 - The oxidation hypothesis proposes that oxidative modification of low density lipoprotein (LDL) plays a critical role in atherogenesis. This review critically evaluates the various mechanisms proposed for LDL oxidation, focusing on insights derived from chemical analysis of human artery wall and studies of genetically engineered mice. The implications of recent clinical trials of vitamin E for the oxidation hypothesis are also briefly discussed.

AB - The oxidation hypothesis proposes that oxidative modification of low density lipoprotein (LDL) plays a critical role in atherogenesis. This review critically evaluates the various mechanisms proposed for LDL oxidation, focusing on insights derived from chemical analysis of human artery wall and studies of genetically engineered mice. The implications of recent clinical trials of vitamin E for the oxidation hypothesis are also briefly discussed.

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U2 - 10.1016/S1050-1738(01)00101-3

DO - 10.1016/S1050-1738(01)00101-3

M3 - Review article

C2 - 11685998

AN - SCOPUS:0035181940

SN - 1050-1738

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SP - 103

EP - 112

JO - Trends in Cardiovascular Medicine

JF - Trends in Cardiovascular Medicine

IS - 3-4

ER -

Mechanisms for oxidizing low-density lipoprotein: Insights from patterns of oxidation products in the artery wall and from mouse models of atherosclerosis

Abstract

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