Mechanisms for oxidizing low-density lipoprotein: Insights from patterns of oxidation products in the artery wall and from mouse models of atherosclerosis

Joseph P. Gaut, Jay W. Heinecke

Research output: Contribution to journalReview articlepeer-review

88 Scopus citations

Abstract

The oxidation hypothesis proposes that oxidative modification of low density lipoprotein (LDL) plays a critical role in atherogenesis. This review critically evaluates the various mechanisms proposed for LDL oxidation, focusing on insights derived from chemical analysis of human artery wall and studies of genetically engineered mice. The implications of recent clinical trials of vitamin E for the oxidation hypothesis are also briefly discussed.

Original languageEnglish
Pages (from-to)103-112
Number of pages10
JournalTrends in Cardiovascular Medicine
Volume11
Issue number3-4
DOIs
StatePublished - Jan 1 2001

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