TY - JOUR
T1 - Mechanism of vitamin D action and its regulation
AU - Dusso, A. S.
AU - Brown, A. J.
PY - 1998
Y1 - 1998
N2 - Most of the biological actions of 1,25(OH)2D3, the hormonal form of vitamin D, are mediated by the vitamin D receptor (VDR), a member of the steroid/thyroid receptor superfamily. The VDR functions as a ligand-induced transcription factor regulating the rate of expression of genes involved not only in the control of calcium homeostasis and bone remodeling, but also in immunomodulation, the control of hormone secretion, inhibition of cell growth, and induction of cell differentiation. This section discusses the molecular mechanisms involved in the transcriptional control of gene expression by 1,25(OH)2D3.
AB - Most of the biological actions of 1,25(OH)2D3, the hormonal form of vitamin D, are mediated by the vitamin D receptor (VDR), a member of the steroid/thyroid receptor superfamily. The VDR functions as a ligand-induced transcription factor regulating the rate of expression of genes involved not only in the control of calcium homeostasis and bone remodeling, but also in immunomodulation, the control of hormone secretion, inhibition of cell growth, and induction of cell differentiation. This section discusses the molecular mechanisms involved in the transcriptional control of gene expression by 1,25(OH)2D3.
KW - 1,25(OH)D genomic actions
KW - 1,25(OH)D transcriptional regulation
KW - Regulation of vitamin D action
KW - Vitamin D receptor
UR - http://www.scopus.com/inward/record.url?scp=0031736063&partnerID=8YFLogxK
U2 - 10.1053/ajkd.1998.v32.pm9808140
DO - 10.1053/ajkd.1998.v32.pm9808140
M3 - Article
C2 - 9808140
AN - SCOPUS:0031736063
SN - 0272-6386
VL - 32
SP - S13-S24
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 4 SUPPL. 2
ER -