Abstract
In isolated perfused rabbit hearts, bradykinin produced a concentration dependent decrease in coronary resistance directly associated with biosynthesis and release of prostaglandin E like substance. An inhibitor of bradykinin destruction (the nonapeptide SQ 20881) markedly enhanced both the coronary vasodilation and release of prostaglandin E like substance produced by cardiac injection of bradykinin. Indomethacin inhibited both the myocardial prostaglandin biosynthesis and the decrease in coronary resistance induced by bradykinin. The demonstration that bradykinin is a potent stimulator of prostaglandin biosynthesis in the heart has implications as to the cause of the afferent cardiovascular reflexes and pain in myocardial infarction and angina pectoris.
| Original language | English |
|---|---|
| Pages (from-to) | 2060-2063 |
| Number of pages | 4 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 72 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1975 |
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