Mechanism and modification of bradykinin induced coronary vasodilation

P. Needleman, S. L. Key, S. E. Denny, P. C. Isakson, G. R. Marshall

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In isolated perfused rabbit hearts, bradykinin produced a concentration dependent decrease in coronary resistance directly associated with biosynthesis and release of prostaglandin E like substance. An inhibitor of bradykinin destruction (the nonapeptide SQ 20881) markedly enhanced both the coronary vasodilation and release of prostaglandin E like substance produced by cardiac injection of bradykinin. Indomethacin inhibited both the myocardial prostaglandin biosynthesis and the decrease in coronary resistance induced by bradykinin. The demonstration that bradykinin is a potent stimulator of prostaglandin biosynthesis in the heart has implications as to the cause of the afferent cardiovascular reflexes and pain in myocardial infarction and angina pectoris.

Original languageEnglish
Pages (from-to)2060-2063
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number6
StatePublished - 1975


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