Measuring propargyl-linked drug populations inside bacterial cells, and their interaction with a dihydrofolate reductase target, by Raman microscopy

Keyphrases

• Escherichia Coli 100%
• Bacterial Cells 100%
• Methylenetetrahydrofolate Reductase (MTHFR) 100%
• Propargyl 100%
• Raman Microscopy 100%
• Staphylococcus Aureus 66%
• Klebsiella Pneumoniae (K. pneumoniae) 66%
• Protonation 66%
• Dihydrofolate Reductase Inhibitors 66%
• Cell-to-cell 33%
• Drug Exposure 33%
• Raman Spectroscopy 33%
• Single Crystal 33%
• Gram-negative 33%
• Extracellular Products 33%
• Spectroscopic Studies 33%
• Differential Spectrum 33%
• Novel Protocol 33%
• Gram-positive Bacterial 33%
• Freeze-dried Cells 33%
• Diaminopyrimidine 33%
• In-situ Comparison 33%
• Spectroscopic Characteristics 33%
• Raman Peak 33%
• Fermentation Medium 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Escherichia coli 100%
• Dihydrofolate Reductase 100%
• Raman Microscopy 100%
• Staphylococcus Aureus 66%
• Dihydrofolate Reductase Inhibitor 66%
• Klebsiella pneumoniae 33%
• Alginic Acid 33%

Chemistry

• Dihydrofolates 100%
• Dihydrofolate Reductase Inhibitor 66%
• protonation 66%
• Single Crystalline Solid 33%
• Spectroscopy 33%