Measurement of upregulation of inducible nitric oxide synthase in the experimental autoimmune encephalomyelitis model using a positron emitting radiopharmaceutical

Jian Zhang, Anne H. Cross, Timothy J. McCarthy, Michael J. Welch

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Excess nitric oxide has been implicated in the pathogenosis of experimental autoimmune encephalomyelitis (EAE) which is an animal model for multiple sclerosis. Positron emission tomography (PET) is an imaging technique that has shown utility for studying enzyme systems in vivo. A positron-labeled inducible nitric oxide synthetase (iNOS) inhibitor has been studied in EAE-affected mice as well as controls. Greater uptake of the radiolabeled inhibitor was observed in the spinal cord of the affected mice than of control mice. Increased uptake was also observed in other organs not previously implicated in this experimental model. The increased up-take of the radiopharmaceutical in this model suggests that this tracer may have the potential for measuring increased levels of iNOS in humans by PET.

Original languageEnglish
Pages (from-to)263-267
Number of pages5
JournalNitric Oxide - Biology and Chemistry
Volume1
Issue number3
DOIs
StatePublished - Jun 1997

Keywords

  • Encephalomyelitis
  • Enzyme systems
  • Multiple sclerosis
  • Nitric oxide synthase
  • Positron emission tomography (PET)
  • Radiopharmaceutical

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