Measurement of regional substrate utilization rates by emission tomography

M. E. Raichle; M. J. Welch; R. L. Grubb; C. S. Higgins; M. M. Ter-Pogossian; K. B. Larson

doi:10.1126/science.414358

Measurement of regional substrate utilization rates by emission tomography

M. E. Raichle, M. J. Welch, R. L. Grubb, C. S. Higgins, M. M. Ter-Pogossian, K. B. Larson

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42 Scopus citations

Abstract

Emission tomography can be used to monitor, in vivo and regionally, the utilization of metabolic substrates labeled with positron-emitting radioisotopes produced by a cyclotron. The concept was validated by measuring brain glucose utilization with carbon-11-labeled glucose in rhesus monkeys.

Original language	English
Pages (from-to)	986-987
Number of pages	2
Journal	Science
Volume	199
Issue number	4332
DOIs	https://doi.org/10.1126/science.414358
State	Published - 1978

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@article{5e04469840804800a4222644e9cf9057,

title = "Measurement of regional substrate utilization rates by emission tomography",

abstract = "Emission tomography can be used to monitor, in vivo and regionally, the utilization of metabolic substrates labeled with positron-emitting radioisotopes produced by a cyclotron. The concept was validated by measuring brain glucose utilization with carbon-11-labeled glucose in rhesus monkeys.",

author = "Raichle, {M. E.} and Welch, {M. J.} and Grubb, {R. L.} and Higgins, {C. S.} and Ter-Pogossian, {M. M.} and Larson, {K. B.}",

year = "1978",

doi = "10.1126/science.414358",

language = "English",

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AU - Raichle, M. E.

AU - Welch, M. J.

AU - Grubb, R. L.

AU - Higgins, C. S.

AU - Ter-Pogossian, M. M.

AU - Larson, K. B.

PY - 1978

Y1 - 1978

N2 - Emission tomography can be used to monitor, in vivo and regionally, the utilization of metabolic substrates labeled with positron-emitting radioisotopes produced by a cyclotron. The concept was validated by measuring brain glucose utilization with carbon-11-labeled glucose in rhesus monkeys.

AB - Emission tomography can be used to monitor, in vivo and regionally, the utilization of metabolic substrates labeled with positron-emitting radioisotopes produced by a cyclotron. The concept was validated by measuring brain glucose utilization with carbon-11-labeled glucose in rhesus monkeys.

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U2 - 10.1126/science.414358

DO - 10.1126/science.414358

M3 - Article

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AN - SCOPUS:0017893535

SN - 0036-8075

VL - 199

SP - 986

EP - 987

JO - Science

JF - Science

IS - 4332

ER -

Measurement of regional substrate utilization rates by emission tomography

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