TY - GEN
T1 - Measurement of elastin expression after in vitro application of potassium channel openers in RFL6 cells
AU - Jaya, Parulekar
AU - Wagenseil, J.
AU - Staiculescu, C.
PY - 2014
Y1 - 2014
N2 - The goal of this study is to develop an in vitro assay for elastin expression using RFL6 cells, which were derived from fibroblasts present in rat lung tissue, and to test different doses of minoxidil and diazoxide, potent vasodilators and potassium channel openers. Elastin amounts in response to drug treatments are assessed using a commercial Fastin Elastin assay. Our project will shed light on optimal pharmaceutical doses for increasing elastin expression and also provide a relatively high throughput method for testing additional anti-hypertensive drugs that may affect elastin expression and subsequently decrease arterial stiffness and blood pressure.Grant: Acknowledgements: Funding by the AMGEN Scholars Program, NIH grants HL105314 and HL115560 and Washington University in St. Louis are gratefully acknowledged.
AB - The goal of this study is to develop an in vitro assay for elastin expression using RFL6 cells, which were derived from fibroblasts present in rat lung tissue, and to test different doses of minoxidil and diazoxide, potent vasodilators and potassium channel openers. Elastin amounts in response to drug treatments are assessed using a commercial Fastin Elastin assay. Our project will shed light on optimal pharmaceutical doses for increasing elastin expression and also provide a relatively high throughput method for testing additional anti-hypertensive drugs that may affect elastin expression and subsequently decrease arterial stiffness and blood pressure.Grant: Acknowledgements: Funding by the AMGEN Scholars Program, NIH grants HL105314 and HL115560 and Washington University in St. Louis are gratefully acknowledged.
UR - http://www.scopus.com/inward/record.url?scp=84958568921&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84958568921
T3 - Student Poster Sessions 2014 - Core Programming Area at the 2014 AIChE Annual Meeting
SP - 181
EP - 182
BT - Student Poster Sessions 2014 - Core Programming Area at the 2014 AIChE Annual Meeting
PB - AIChE
T2 - Student Poster Sessions 2014 - Core Programming Area at the 2014 AIChE Annual Meeting
Y2 - 16 November 2014 through 21 November 2014
ER -