Measurement of brain oxygen utilization with radioactive oxygen 15: experimental verification

M. E. Raichle, R. L. Grubb, J. O. Eichling, M. M. Ter Pogossian

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Abstract

This study was designed to provide direct experimental evidence in support of the method employing radioactive 15O-tagged hemoglobin for the in vivo and regional measurement of the cerebral oxygen utilization rate (CMRO2). This was accomplished by simultaneously measuring in vivo the mean CMRO2 in monkeys and human beings by the 15O method and a direct appeal to the Fick principle using measured arteriovenous oxygen differences of brain. The correlation between the 2 methods was excellent, with a correlation of 0.90 (P< 0.001) in monkeys and 0.88 (P < 0.001) in human beings.

Original languageEnglish
Pages (from-to)638-640
Number of pages3
JournalJournal of Applied Physiology
Volume40
Issue number4
DOIs
StatePublished - Jan 1 1976

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