TY - JOUR
T1 - Measurement of brain oxygen utilization with radioactive oxygen 15
T2 - experimental verification
AU - Raichle, M. E.
AU - Grubb, R. L.
AU - Eichling, J. O.
AU - Ter Pogossian, M. M.
PY - 1976/1/1
Y1 - 1976/1/1
N2 - This study was designed to provide direct experimental evidence in support of the method employing radioactive 15O-tagged hemoglobin for the in vivo and regional measurement of the cerebral oxygen utilization rate (CMRO2). This was accomplished by simultaneously measuring in vivo the mean CMRO2 in monkeys and human beings by the 15O method and a direct appeal to the Fick principle using measured arteriovenous oxygen differences of brain. The correlation between the 2 methods was excellent, with a correlation of 0.90 (P< 0.001) in monkeys and 0.88 (P < 0.001) in human beings.
AB - This study was designed to provide direct experimental evidence in support of the method employing radioactive 15O-tagged hemoglobin for the in vivo and regional measurement of the cerebral oxygen utilization rate (CMRO2). This was accomplished by simultaneously measuring in vivo the mean CMRO2 in monkeys and human beings by the 15O method and a direct appeal to the Fick principle using measured arteriovenous oxygen differences of brain. The correlation between the 2 methods was excellent, with a correlation of 0.90 (P< 0.001) in monkeys and 0.88 (P < 0.001) in human beings.
UR - http://www.scopus.com/inward/record.url?scp=0017294272&partnerID=8YFLogxK
U2 - 10.1152/jappl.1976.40.4.638
DO - 10.1152/jappl.1976.40.4.638
M3 - Article
C2 - 931886
AN - SCOPUS:0017294272
SN - 8750-7587
VL - 40
SP - 638
EP - 640
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
IS - 4
ER -