TY - GEN
T1 - Measurement of brain biomechanics in vivo by magnetic resonance imaging
AU - Bayly, P. V.
AU - Clayton, E. H.
AU - Feng, Y.
AU - Abney, T.
AU - Namani, R.
AU - Okamoto, R. J.
AU - Genin, G. M.
PY - 2012
Y1 - 2012
N2 - Computer models of head-brain biomechanics offer enormous potential for improved understanding and prevention of traumatic brain injury (TBI). However existing computer models remain controversial because their predictions have yet to be rigorously compared to measured biomechanical data. The nonlinear, anisotropic, viscoelastic, heterogeneous character of brain tissue, and the intricate connections between the brain and skull, all complicate modeling efforts. In order to make progress toward the goal of accurate simulation of TBI, experimental techniques to address these issues must be developed. In this paper we describe two magnetic resonance (MR) imaging techniques to characterize brain deformation, estimate brain material properties, and illuminate the boundary conditions between brain and skull. MR tagging is used to estimate displacement and strain fields in response to rigid-body acceleration of the skull, and MR elastography is used to visualize shear wave propagation induced by oscillatory loading at the surface of the skull.
AB - Computer models of head-brain biomechanics offer enormous potential for improved understanding and prevention of traumatic brain injury (TBI). However existing computer models remain controversial because their predictions have yet to be rigorously compared to measured biomechanical data. The nonlinear, anisotropic, viscoelastic, heterogeneous character of brain tissue, and the intricate connections between the brain and skull, all complicate modeling efforts. In order to make progress toward the goal of accurate simulation of TBI, experimental techniques to address these issues must be developed. In this paper we describe two magnetic resonance (MR) imaging techniques to characterize brain deformation, estimate brain material properties, and illuminate the boundary conditions between brain and skull. MR tagging is used to estimate displacement and strain fields in response to rigid-body acceleration of the skull, and MR elastography is used to visualize shear wave propagation induced by oscillatory loading at the surface of the skull.
UR - http://www.scopus.com/inward/record.url?scp=84867207819&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84867207819
SN - 9781441995285
T3 - Conference Proceedings of the Society for Experimental Mechanics Series
SP - 117
EP - 128
BT - Applications of Imaging Techniques to Mechanics of Materials and Structures - Proceedings of the 2010 Annual Conference on Experimental and Appied Mechanics
T2 - 2010 Annual Conference on Experimental and Applied Mechanics
Y2 - 7 June 2010 through 10 June 2010
ER -