TY - JOUR
T1 - Means, mechanisms and consequences of adenine methylation in DNA
AU - Boulias, Konstantinos
AU - Greer, Eric Lieberman
N1 - Publisher Copyright:
© 2022, Springer Nature Limited.
PY - 2022/7
Y1 - 2022/7
N2 - N6-methyl-2′-deoxyadenosine (6mA or m6dA) has been reported in the DNA of prokaryotes and eukaryotes ranging from unicellular protozoa and algae to multicellular plants and mammals. It has been proposed to modulate DNA structure and transcription, transmit information across generations and have a role in disease, among other functions. However, its existence in more recently evolved eukaryotes remains a topic of debate. Recent technological advancements have facilitated the identification and quantification of 6mA even when the modification is exceptionally rare, but each approach has limitations. Critical assessment of existing data, rigorous design of future studies and further development of methods will be required to confirm the presence and biological functions of 6mA in multicellular eukaryotes.
AB - N6-methyl-2′-deoxyadenosine (6mA or m6dA) has been reported in the DNA of prokaryotes and eukaryotes ranging from unicellular protozoa and algae to multicellular plants and mammals. It has been proposed to modulate DNA structure and transcription, transmit information across generations and have a role in disease, among other functions. However, its existence in more recently evolved eukaryotes remains a topic of debate. Recent technological advancements have facilitated the identification and quantification of 6mA even when the modification is exceptionally rare, but each approach has limitations. Critical assessment of existing data, rigorous design of future studies and further development of methods will be required to confirm the presence and biological functions of 6mA in multicellular eukaryotes.
UR - http://www.scopus.com/inward/record.url?scp=85125714604&partnerID=8YFLogxK
U2 - 10.1038/s41576-022-00456-x
DO - 10.1038/s41576-022-00456-x
M3 - Review article
C2 - 35256817
AN - SCOPUS:85125714604
SN - 1471-0056
VL - 23
SP - 411
EP - 428
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 7
ER -