TY - JOUR
T1 - Meaningful associations in the adolescent brain cognitive development study
AU - Dick, Anthony Steven
AU - Lopez, Daniel A.
AU - Watts, Ashley L.
AU - Heeringa, Steven
AU - Reuter, Chase
AU - Bartsch, Hauke
AU - Fan, Chun Chieh
AU - Kennedy, David N.
AU - Palmer, Clare
AU - Marshall, Andrew
AU - Haist, Frank
AU - Hawes, Samuel
AU - Nichols, Thomas E.
AU - Barch, Deanna M.
AU - Jernigan, Terry L.
AU - Garavan, Hugh
AU - Grant, Steven
AU - Pariyadath, Vani
AU - Hoffman, Elizabeth
AU - Neale, Michael
AU - Stuart, Elizabeth A.
AU - Paulus, Martin P.
AU - Sher, Kenneth J.
AU - Thompson, Wesley K.
N1 - Publisher Copyright:
© 2021 The Author(s)
PY - 2021/10/1
Y1 - 2021/10/1
N2 - The Adolescent Brain Cognitive Development (ABCD) Study is the largest single-cohort prospective longitudinal study of neurodevelopment and children's health in the United States. A cohort of n = 11,880 children aged 9–10 years (and their parents/guardians) were recruited across 22 sites and are being followed with in-person visits on an annual basis for at least 10 years. The study approximates the US population on several key sociodemographic variables, including sex, race, ethnicity, household income, and parental education. Data collected include assessments of health, mental health, substance use, culture and environment and neurocognition, as well as geocoded exposures, structural and functional magnetic resonance imaging (MRI), and whole-genome genotyping. Here, we describe the ABCD Study aims and design, as well as issues surrounding estimation of meaningful associations using its data, including population inferences, hypothesis testing, power and precision, control of covariates, interpretation of associations, and recommended best practices for reproducible research, analytical procedures and reporting of results.
AB - The Adolescent Brain Cognitive Development (ABCD) Study is the largest single-cohort prospective longitudinal study of neurodevelopment and children's health in the United States. A cohort of n = 11,880 children aged 9–10 years (and their parents/guardians) were recruited across 22 sites and are being followed with in-person visits on an annual basis for at least 10 years. The study approximates the US population on several key sociodemographic variables, including sex, race, ethnicity, household income, and parental education. Data collected include assessments of health, mental health, substance use, culture and environment and neurocognition, as well as geocoded exposures, structural and functional magnetic resonance imaging (MRI), and whole-genome genotyping. Here, we describe the ABCD Study aims and design, as well as issues surrounding estimation of meaningful associations using its data, including population inferences, hypothesis testing, power and precision, control of covariates, interpretation of associations, and recommended best practices for reproducible research, analytical procedures and reporting of results.
KW - Adolescent brain cognitive development study
KW - Covariate Adjustments
KW - Effect Sizes
KW - Genetics
KW - Hypothesis testing
KW - Population neuroscience
KW - Reproducibility
UR - http://www.scopus.com/inward/record.url?scp=85108869179&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2021.118262
DO - 10.1016/j.neuroimage.2021.118262
M3 - Review article
C2 - 34147629
AN - SCOPUS:85108869179
SN - 1053-8119
VL - 239
JO - NeuroImage
JF - NeuroImage
M1 - 118262
ER -