Mda-7/IL-24: A unique member of the IL-10 gene family promoting cancer-targeted toxicity

Rupesh Dash, Sujit K. Bhutia, Belal Azab, Zhao zhong Su, Bridget A. Quinn, Timothy P. Kegelmen, Swadesh K. Das, Keetae Kim, Seok Geun Lee, Margaret A. Park, Adly Yacoub, Mohammed Rahmani, Luni Emdad, Igor P. Dmitriev, Xiang Yang Wang, Devanand Sarkar, Steven Grant, Paul Dent, David T. Curiel, Paul B. Fisher

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a unique member of the IL-10 gene family that displays nearly ubiquitous cancer-specific toxicity, with no harmful effects toward normal cells or tissues. mda-7/IL-24 was cloned from human melanoma cells by differentiation induction subtraction hybridization (DISH) and promotes endoplasmic reticulum (ER) stress culminating in apoptosis or toxic autophagy in a broad-spectrum of human cancers, when assayed in cell culture, in vivo in human tumor xenograft mouse models and in a Phase I clinical trial in patients with advanced cancers. This therapeutically active cytokine also induces indirect antitumor activity through inhibition of angiogenesis, stimulation of an antitumor immune response, and sensitization of cancer cells to radiation-, chemotherapy- and antibody-induced killing.

Original languageEnglish
Pages (from-to)381-391
Number of pages11
JournalCytokine and Growth Factor Reviews
Volume21
Issue number5
DOIs
StatePublished - Oct 2010

Keywords

  • Apoptosis
  • Autophagy
  • Bystander antitumor activity
  • Cancer terminator virus
  • Mda-7/IL-24

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