TY - JOUR
T1 - MCL1 enhances the survival of CD8+ memory T cells after viral infection
AU - Gui, Jingang
AU - Hu, Zhuting
AU - Tsai, Ching Yi
AU - Ma, Tian
AU - Song, Yan
AU - Morales, Amanda
AU - Huang, Li Hao
AU - Dmitrovsky, Ethan
AU - Craig, Ruth W.
AU - Usherwood, Edward J.
N1 - Publisher Copyright:
© 2015, American Society for Microbiology.
PY - 2015
Y1 - 2015
N2 - Viral infection results in the generation of massive numbers of activated effector CD8+ T cells that recognize viral components. Most of these are short-lived effector T cells (SLECs) that die after clearance of the virus. However, a small proportion of this population survives and forms antigen-specific memory precursor effector cells (MPECs), which ultimately develop into memory cells. These can participate in a recall response upon reexposure to antigen even at protracted times postinfection. Here, antiapoptotic myeloid cell leukemia 1 (MCL1) was found to prolong survival upon T cell stimulation, and mice expressing human MCL1 as a transgene exhibited a skewing in the proportion of CD8+ T cells, away from SLECs toward MPECs, during the acute phase of vaccinia virus infection. A higher frequency and total number of antigen-specific CD8+ T cells were observed in MCL1 transgenic mice. These findings show that MCL1 can shape the makeup of the CD8+ T cell response, promoting the formation of long-term memory.
AB - Viral infection results in the generation of massive numbers of activated effector CD8+ T cells that recognize viral components. Most of these are short-lived effector T cells (SLECs) that die after clearance of the virus. However, a small proportion of this population survives and forms antigen-specific memory precursor effector cells (MPECs), which ultimately develop into memory cells. These can participate in a recall response upon reexposure to antigen even at protracted times postinfection. Here, antiapoptotic myeloid cell leukemia 1 (MCL1) was found to prolong survival upon T cell stimulation, and mice expressing human MCL1 as a transgene exhibited a skewing in the proportion of CD8+ T cells, away from SLECs toward MPECs, during the acute phase of vaccinia virus infection. A higher frequency and total number of antigen-specific CD8+ T cells were observed in MCL1 transgenic mice. These findings show that MCL1 can shape the makeup of the CD8+ T cell response, promoting the formation of long-term memory.
UR - http://www.scopus.com/inward/record.url?scp=84921652871&partnerID=8YFLogxK
U2 - 10.1128/JVI.02480-14
DO - 10.1128/JVI.02480-14
M3 - Article
C2 - 25505074
AN - SCOPUS:84921652871
SN - 0022-538X
VL - 89
SP - 2405
EP - 2414
JO - Journal of virology
JF - Journal of virology
IS - 4
ER -