Maximal testosterone suppression in prostate cancer - Free vs total testosterone

Kyle O. Rove, E. David Crawford, Massimo Perachino, Juan Morote, Laurence Klotz, Paul H. Lange, Gerald L. Andriole, Alvin M. Matsumoto, Samir S. Taneja, Mario A. Eisenberger, Leonardo O. Reis

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Testosterone remains a key target in the treatment of advanced prostate cancer. The relationship of free testosterone to prostate cancer treatment and outcomes remains largely unexplored. A consensus of prostate cancer experts was convened in 2013 to review current knowledge surrounding relationship of total and free testosterone to prostate cancer, discuss the free hormone hypothesis, and highlight future avenues for therapeutics. Free testosterone may better reflect prostate cancer tissue androgen levels than serum total testosterone concentration. Free testosterone deserves more research regarding its relation to clinical outcomes.

Original languageEnglish
Pages (from-to)1217-1222
Number of pages6
Issue number6
StatePublished - Jun 2014


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