TY - JOUR
T1 - Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide
AU - Russell, John H.
AU - Rush, Brian
AU - Weaver, Casey
AU - Wang, Ruduan
PY - 1993/5/15
Y1 - 1993/5/15
N2 - Antigen receptor-stimulated cell death of developing, immature T cells plays an important role in shaping the repertoire of antigens to which mature T cells will respond, but a role for receptor-stimulated death in controlling responses of mature T cells is controversial. Mutant lpr/lpr mice exhibit an autoimmune syndrome similar to systemic lupus erythematosus. Here we demonstrate that these mice have a defect in antigen-stimulated suicide of activated T cells in mature CD4+ and CD8+ T cell compartments. The defective suicide pathway is evident when the T cells are stimulated with antigen on antigen-presenting cells or with immobilized anti-CD3 in the absence of antigen-presenting cells. These studies, in concert with the work of others, suggest that antigen-stimulated death of mature cells may be important both in establishing peripheral tolerance and in limiting inflammation during normal immune responses.
AB - Antigen receptor-stimulated cell death of developing, immature T cells plays an important role in shaping the repertoire of antigens to which mature T cells will respond, but a role for receptor-stimulated death in controlling responses of mature T cells is controversial. Mutant lpr/lpr mice exhibit an autoimmune syndrome similar to systemic lupus erythematosus. Here we demonstrate that these mice have a defect in antigen-stimulated suicide of activated T cells in mature CD4+ and CD8+ T cell compartments. The defective suicide pathway is evident when the T cells are stimulated with antigen on antigen-presenting cells or with immobilized anti-CD3 in the absence of antigen-presenting cells. These studies, in concert with the work of others, suggest that antigen-stimulated death of mature cells may be important both in establishing peripheral tolerance and in limiting inflammation during normal immune responses.
KW - Apoptosis
KW - Autoimmunity
KW - Programmed cell death
KW - Tolerance
UR - http://www.scopus.com/inward/record.url?scp=0027314703&partnerID=8YFLogxK
U2 - 10.1073/pnas.90.10.4409
DO - 10.1073/pnas.90.10.4409
M3 - Article
C2 - 8506280
AN - SCOPUS:0027314703
SN - 0027-8424
VL - 90
SP - 4409
EP - 4413
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 10
ER -