Maturation of large-scale brain systems over the first month of life

Ashley N. Nielsen; Sydney Kaplan; Dominique Meyer; Dimitrios Alexopoulos; Jeanette K. Kenley; Tara A. Smyser; Lauren S. Wakschlag; Elizabeth S. Norton; Nandini Raghuraman; Barbara B. Warner; Joshua S. Shimony; Joan L. Luby; Jeffery J. Neil; Steven E. Petersen; Deanna M. Barch; Cynthia E. Rogers; Chad M. Sylvester; Christopher D. Smyser

doi:10.1093/cercor/bhac242

Maturation of large-scale brain systems over the first month of life

Ashley N. Nielsen, Sydney Kaplan, Dominique Meyer, Dimitrios Alexopoulos, Jeanette K. Kenley, Tara A. Smyser, Lauren S. Wakschlag, Elizabeth S. Norton, Nandini Raghuraman, Barbara B. Warner, Joshua S. Shimony, Joan L. Luby, Jeffery J. Neil, Steven E. Petersen, Deanna M. Barch, Cynthia E. Rogers, Chad M. Sylvester, Christopher D. Smyser

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The period immediately after birth is a critical developmental window, capturing rapid maturation of brain structure and a child's earliest experiences. Large-scale brain systems are present at delivery, but how these brain systems mature during this narrow window (i.e. first weeks of life) marked by heightened neuroplasticity remains uncharted. Using multivariate pattern classification techniques and functional connectivity magnetic resonance imaging, we detected robust differences in brain systems related to age in newborns (n = 262; R2 = 0.51). Development over the first month of life occurred brain-wide, but differed and was more pronounced in brain systems previously characterized as developing early (i.e. sensorimotor networks) than in those characterized as developing late (i.e. association networks). The cingulo-opercular network was the only exception to this organizing principle, illuminating its early role in brain development. This study represents a step towards a normative brain "growth curve"that could be used to identify atypical brain maturation in infancy.

Original language	English
Pages (from-to)	2788-2803
Number of pages	16
Journal	Cerebral Cortex
Volume	33
Issue number	6
DOIs	https://doi.org/10.1093/cercor/bhac242
State	Published - Mar 15 2023

Keywords

development
fMRI
functional connectivity
infant
machine learning

Access to Document

10.1093/cercor/bhac242

Cite this

Nielsen, A. N., Kaplan, S., Meyer, D., Alexopoulos, D., Kenley, J. K., Smyser, T. A., Wakschlag, L. S., Norton, E. S., Raghuraman, N., Warner, B. B., Shimony, J. S., Luby, J. L., Neil, J. J., Petersen, S. E., Barch, D. M., Rogers, C. E., Sylvester, C. M., & Smyser, C. D. (2023). Maturation of large-scale brain systems over the first month of life. Cerebral Cortex, 33(6), 2788-2803. https://doi.org/10.1093/cercor/bhac242

@article{b4e9c35d9bde49c48d5b60b25f92a706,

title = "Maturation of large-scale brain systems over the first month of life",

abstract = "The period immediately after birth is a critical developmental window, capturing rapid maturation of brain structure and a child's earliest experiences. Large-scale brain systems are present at delivery, but how these brain systems mature during this narrow window (i.e. first weeks of life) marked by heightened neuroplasticity remains uncharted. Using multivariate pattern classification techniques and functional connectivity magnetic resonance imaging, we detected robust differences in brain systems related to age in newborns (n = 262; R2 = 0.51). Development over the first month of life occurred brain-wide, but differed and was more pronounced in brain systems previously characterized as developing early (i.e. sensorimotor networks) than in those characterized as developing late (i.e. association networks). The cingulo-opercular network was the only exception to this organizing principle, illuminating its early role in brain development. This study represents a step towards a normative brain {"}growth curve{"}that could be used to identify atypical brain maturation in infancy.",

keywords = "development, fMRI, functional connectivity, infant, machine learning",

author = "Nielsen, {Ashley N.} and Sydney Kaplan and Dominique Meyer and Dimitrios Alexopoulos and Kenley, {Jeanette K.} and Smyser, {Tara A.} and Wakschlag, {Lauren S.} and Norton, {Elizabeth S.} and Nandini Raghuraman and Warner, {Barbara B.} and Shimony, {Joshua S.} and Luby, {Joan L.} and Neil, {Jeffery J.} and Petersen, {Steven E.} and Barch, {Deanna M.} and Rogers, {Cynthia E.} and Sylvester, {Chad M.} and Smyser, {Christopher D.}",

year = "2023",

month = mar,

day = "15",

doi = "10.1093/cercor/bhac242",

language = "English",

volume = "33",

pages = "2788--2803",

journal = "Cerebral Cortex",

issn = "1047-3211",

number = "6",

}

Nielsen, AN, Kaplan, S, Meyer, D, Alexopoulos, D, Kenley, JK, Smyser, TA, Wakschlag, LS, Norton, ES, Raghuraman, N , Warner, BB , Shimony, JS , Luby, JL , Neil, JJ, Petersen, SE, Barch, DM , Rogers, CE , Sylvester, CM & Smyser, CD 2023, 'Maturation of large-scale brain systems over the first month of life', Cerebral Cortex, vol. 33, no. 6, pp. 2788-2803. https://doi.org/10.1093/cercor/bhac242

TY - JOUR

T1 - Maturation of large-scale brain systems over the first month of life

AU - Nielsen, Ashley N.

AU - Kaplan, Sydney

AU - Meyer, Dominique

AU - Alexopoulos, Dimitrios

AU - Kenley, Jeanette K.

AU - Smyser, Tara A.

AU - Wakschlag, Lauren S.

AU - Norton, Elizabeth S.

AU - Raghuraman, Nandini

AU - Warner, Barbara B.

AU - Shimony, Joshua S.

AU - Luby, Joan L.

AU - Neil, Jeffery J.

AU - Petersen, Steven E.

AU - Barch, Deanna M.

AU - Rogers, Cynthia E.

AU - Sylvester, Chad M.

AU - Smyser, Christopher D.

PY - 2023/3/15

Y1 - 2023/3/15

N2 - The period immediately after birth is a critical developmental window, capturing rapid maturation of brain structure and a child's earliest experiences. Large-scale brain systems are present at delivery, but how these brain systems mature during this narrow window (i.e. first weeks of life) marked by heightened neuroplasticity remains uncharted. Using multivariate pattern classification techniques and functional connectivity magnetic resonance imaging, we detected robust differences in brain systems related to age in newborns (n = 262; R2 = 0.51). Development over the first month of life occurred brain-wide, but differed and was more pronounced in brain systems previously characterized as developing early (i.e. sensorimotor networks) than in those characterized as developing late (i.e. association networks). The cingulo-opercular network was the only exception to this organizing principle, illuminating its early role in brain development. This study represents a step towards a normative brain "growth curve"that could be used to identify atypical brain maturation in infancy.

AB - The period immediately after birth is a critical developmental window, capturing rapid maturation of brain structure and a child's earliest experiences. Large-scale brain systems are present at delivery, but how these brain systems mature during this narrow window (i.e. first weeks of life) marked by heightened neuroplasticity remains uncharted. Using multivariate pattern classification techniques and functional connectivity magnetic resonance imaging, we detected robust differences in brain systems related to age in newborns (n = 262; R2 = 0.51). Development over the first month of life occurred brain-wide, but differed and was more pronounced in brain systems previously characterized as developing early (i.e. sensorimotor networks) than in those characterized as developing late (i.e. association networks). The cingulo-opercular network was the only exception to this organizing principle, illuminating its early role in brain development. This study represents a step towards a normative brain "growth curve"that could be used to identify atypical brain maturation in infancy.

KW - development

KW - fMRI

KW - functional connectivity

KW - infant

KW - machine learning

UR - http://www.scopus.com/inward/record.url?scp=85146760551&partnerID=8YFLogxK

U2 - 10.1093/cercor/bhac242

DO - 10.1093/cercor/bhac242

M3 - Article

C2 - 35750056

AN - SCOPUS:85146760551

SN - 1047-3211

VL - 33

SP - 2788

EP - 2803

JO - Cerebral Cortex

JF - Cerebral Cortex

IS - 6

ER -

Maturation of large-scale brain systems over the first month of life

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this