TY - JOUR
T1 - Maturation, activation, and protection of dendritic cells induced by double-stranded RNA
AU - Cella, Marina
AU - Salio, Mariolina
AU - Sakakibara, Yoichi
AU - Langen, Hanno
AU - Julkunen, Ilkka
AU - Lanzavecchia, Antonio
PY - 1999/3/1
Y1 - 1999/3/1
N2 - The initiation of an immune response is critically dependent on the activation of dendritic cells (DCs). This process is triggered by surface receptors specific for inflammatory cytokines or for conserved patterns characteristic of infectious agents. Here we show that human DCs are activated by influenza virus infection and by double-stranded (ds)RNA. This activation results not only in increased antigen presentation and T cell stimulatory capacity, but also in resistance to the cytopathic effect of the virus, mediated by the production of type I interferon, and upregulation of MxA. Because dsRNA stimulates both maturation and resistance, DCs can serve as altruistic antigen-presenting cells capable of sustaining vital antigen production while acquiring the capacity to trigger naive T cells and drive polarized T helper cell type 1 responses.
AB - The initiation of an immune response is critically dependent on the activation of dendritic cells (DCs). This process is triggered by surface receptors specific for inflammatory cytokines or for conserved patterns characteristic of infectious agents. Here we show that human DCs are activated by influenza virus infection and by double-stranded (ds)RNA. This activation results not only in increased antigen presentation and T cell stimulatory capacity, but also in resistance to the cytopathic effect of the virus, mediated by the production of type I interferon, and upregulation of MxA. Because dsRNA stimulates both maturation and resistance, DCs can serve as altruistic antigen-presenting cells capable of sustaining vital antigen production while acquiring the capacity to trigger naive T cells and drive polarized T helper cell type 1 responses.
KW - Dendritic cell maturation and activation
KW - Double-stranded RNA
KW - Influenza virus
KW - MxA
KW - Type I interferon
UR - http://www.scopus.com/inward/record.url?scp=0033103128&partnerID=8YFLogxK
U2 - 10.1084/jem.189.5.821
DO - 10.1084/jem.189.5.821
M3 - Article
C2 - 10049946
AN - SCOPUS:0033103128
SN - 0022-1007
VL - 189
SP - 821
EP - 829
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 5
ER -