Matrix metalloproteinases in peripheral vascular disease

Mark J. Hobeika, Robert W. Thompson, Bart E. Muhs, Peter C. Brooks, Paul J. Gagne

Research output: Contribution to journalReview article

93 Scopus citations

Abstract

Matrix metalloproteinases (MMPs) are extracellular matrix-modifying enzymes that are important in many physiologic and pathologic vascular processes. Dysregulation of MMP activity has been associated with common vascular diseases such as atherosclerotic plaque formation, abdominal aortic aneurysms, and critical limb ischemia. For this reason, MMPs have become an important focus for basic science studies and clinical investigations by vascular biology researchers. This article reviews the recent literature, summarizing our current understanding of the role of MMPs in the pathogenesis of various peripheral vascular disease states. In addition, the importance of MMPs in the future diagnosis and treatment of peripheral vascular disease is discussed.

Original languageEnglish
Pages (from-to)849-857
Number of pages9
JournalJournal of Vascular Surgery
Volume45
Issue number4
DOIs
StatePublished - Apr 1 2007

Fingerprint Dive into the research topics of 'Matrix metalloproteinases in peripheral vascular disease'. Together they form a unique fingerprint.

  • Cite this