Matrix design for matrix-assisted laser desorption ionization: Sensitive determination of PAH-DNA adducts

M. George; J. M.Y. Wellemans; R. L. Cerny; M. L. Gross; K. Li; E. L. Cavalieri

doi:10.1016/1044-0305(94)80021-9

Matrix design for matrix-assisted laser desorption ionization: Sensitive determination of PAH-DNA adducts

M. George
, J. M.Y. Wellemans
, R. L. Cerny
, M. L. Gross
, K. Li
, E. L. Cavalieri

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Two matrices, 4-phenyl-α-eyanocinnamic acid (PCC) and 4-benzyloxy-α-eyanocinnamic acid (BCC), were identified for the determination of polycyclic aromatic hydrocarbon (PAH) adducts of DNA bases by matrix-assisted laser desorption ionization. These matrices were designed based on the concept that the matrix and the analyte should have structural similarities. PCC is a good matrix for the desorption of not only PAH-modified DNA bases, but also PAHs themselves and their metabolites. Detections can be made at the femtomolar level.

Original language	English
Pages (from-to)	1021-1025
Number of pages	5
Journal	Journal of the American Society for Mass Spectrometry
Volume	5
Issue number	11
DOIs	https://doi.org/10.1016/1044-0305(94)80021-9
State	Published - Nov 1994

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@article{cf9e31f89c064977823b19069e33f444,

title = "Matrix design for matrix-assisted laser desorption ionization: Sensitive determination of PAH-DNA adducts",

abstract = "Two matrices, 4-phenyl-α-eyanocinnamic acid (PCC) and 4-benzyloxy-α-eyanocinnamic acid (BCC), were identified for the determination of polycyclic aromatic hydrocarbon (PAH) adducts of DNA bases by matrix-assisted laser desorption ionization. These matrices were designed based on the concept that the matrix and the analyte should have structural similarities. PCC is a good matrix for the desorption of not only PAH-modified DNA bases, but also PAHs themselves and their metabolites. Detections can be made at the femtomolar level.",

author = "M. George and Wellemans, \{J. M.Y.\} and Cerny, \{R. L.\} and Gross, \{M. L.\} and K. Li and Cavalieri, \{E. L.\}",

note = "Funding Information: This work was supported by the National Institutes of Health (Grant No. lPOlCA49220).",

year = "1994",

month = nov,

doi = "10.1016/1044-0305(94)80021-9",

language = "English",

volume = "5",

pages = "1021--1025",

journal = "Journal of the American Society for Mass Spectrometry",

issn = "1044-0305",

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}

TY - JOUR

T1 - Matrix design for matrix-assisted laser desorption ionization

T2 - Sensitive determination of PAH-DNA adducts

AU - George, M.

AU - Wellemans, J. M.Y.

AU - Cerny, R. L.

AU - Gross, M. L.

AU - Li, K.

AU - Cavalieri, E. L.

N1 - Funding Information: This work was supported by the National Institutes of Health (Grant No. lPOlCA49220).

PY - 1994/11

Y1 - 1994/11

N2 - Two matrices, 4-phenyl-α-eyanocinnamic acid (PCC) and 4-benzyloxy-α-eyanocinnamic acid (BCC), were identified for the determination of polycyclic aromatic hydrocarbon (PAH) adducts of DNA bases by matrix-assisted laser desorption ionization. These matrices were designed based on the concept that the matrix and the analyte should have structural similarities. PCC is a good matrix for the desorption of not only PAH-modified DNA bases, but also PAHs themselves and their metabolites. Detections can be made at the femtomolar level.

AB - Two matrices, 4-phenyl-α-eyanocinnamic acid (PCC) and 4-benzyloxy-α-eyanocinnamic acid (BCC), were identified for the determination of polycyclic aromatic hydrocarbon (PAH) adducts of DNA bases by matrix-assisted laser desorption ionization. These matrices were designed based on the concept that the matrix and the analyte should have structural similarities. PCC is a good matrix for the desorption of not only PAH-modified DNA bases, but also PAHs themselves and their metabolites. Detections can be made at the femtomolar level.

UR - https://www.scopus.com/pages/publications/0001370074

U2 - 10.1016/1044-0305(94)80021-9

DO - 10.1016/1044-0305(94)80021-9

M3 - Article

AN - SCOPUS:0001370074

SN - 1044-0305

VL - 5

SP - 1021

EP - 1025

JO - Journal of the American Society for Mass Spectrometry

JF - Journal of the American Society for Mass Spectrometry

IS - 11

ER -

Matrix design for matrix-assisted laser desorption ionization: Sensitive determination of PAH-DNA adducts

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