TY - JOUR
T1 - Matrix design for matrix-assisted laser desorption ionization
T2 - Sensitive determination of PAH-DNA adducts
AU - George, M.
AU - Wellemans, J. M.Y.
AU - Cerny, R. L.
AU - Gross, M. L.
AU - Li, K.
AU - Cavalieri, E. L.
N1 - Funding Information:
This work was supported by the National Institutes of Health (Grant No. lPOlCA49220).
PY - 1994/11
Y1 - 1994/11
N2 - Two matrices, 4-phenyl-α-eyanocinnamic acid (PCC) and 4-benzyloxy-α-eyanocinnamic acid (BCC), were identified for the determination of polycyclic aromatic hydrocarbon (PAH) adducts of DNA bases by matrix-assisted laser desorption ionization. These matrices were designed based on the concept that the matrix and the analyte should have structural similarities. PCC is a good matrix for the desorption of not only PAH-modified DNA bases, but also PAHs themselves and their metabolites. Detections can be made at the femtomolar level.
AB - Two matrices, 4-phenyl-α-eyanocinnamic acid (PCC) and 4-benzyloxy-α-eyanocinnamic acid (BCC), were identified for the determination of polycyclic aromatic hydrocarbon (PAH) adducts of DNA bases by matrix-assisted laser desorption ionization. These matrices were designed based on the concept that the matrix and the analyte should have structural similarities. PCC is a good matrix for the desorption of not only PAH-modified DNA bases, but also PAHs themselves and their metabolites. Detections can be made at the femtomolar level.
UR - http://www.scopus.com/inward/record.url?scp=0001370074&partnerID=8YFLogxK
U2 - 10.1016/1044-0305(94)80021-9
DO - 10.1016/1044-0305(94)80021-9
M3 - Article
AN - SCOPUS:0001370074
SN - 1044-0305
VL - 5
SP - 1021
EP - 1025
JO - Journal of the American Society for Mass Spectrometry
JF - Journal of the American Society for Mass Spectrometry
IS - 11
ER -