Abstract
Using whole genome expression microarray technology to discover clinically relevant biomarkers for pilocytic astrocytoma (PA), the authors identified matrilin-2 as a unique mRNA overexpressed in PA. Matrilin-2 protein expression was similarly elevated in the majority of sporadic PA, but in only one neurofibromatosis 1-associated PA with an unusually aggressive clinical phenotype. These results suggest that matrilin-2 may be a specific and clinically useful biomarker for discriminating between indolent and clinically aggressive PA.
Original language | English |
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Pages (from-to) | 127-130 |
Number of pages | 4 |
Journal | Neurology |
Volume | 66 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2006 |