Mathematical and physical modeling of actin dynamics in motile cells

Anders E. Carlsson; Alex Mogilner

doi:10.1007/978-90-481-9301-1_16

Mathematical and physical modeling of actin dynamics in motile cells

Anders E. Carlsson, Alex Mogilner

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

5 Scopus citations

Abstract

Mathematical modeling has been very instrumental in aiding traditional experimental methods in uncovering the mysteries of actin dynamics. Here we review recent quantitative models of actin dynamics focusing on ATPATP hydrolysishydrolysis effects, forceforce generation by single actin filaments and networks, self-organization and dynamics of actin networks, dynamics of lamellipodialamellipodia, filopodia and lamella, and integrative mechanochemistry of whole motile cells. We discuss both modeling methods and specific insights from modeling that helped answering biological questions.

Original language	English
Title of host publication	Actin-based Motility
Subtitle of host publication	Cellular, Molecular and Physical Aspects
Publisher	Springer Netherlands
Pages	381-412
Number of pages	32
ISBN (Electronic)	9789048193011
ISBN (Print)	9789048193004
DOIs	https://doi.org/10.1007/978-90-481-9301-1_16
State	Published - 2010

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Mathematical and physical modeling of actin dynamics in motile cells

Abstract

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