Maternal Undernutrition and Fetal Programming: Role of the Placenta

Louiza Belkacemi, D. Michael Nelson, Mina Desai, Michael G. Ross

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

7 Scopus citations
Original languageEnglish
Title of host publicationThe Placenta
Subtitle of host publicationFrom Development to Disease
PublisherWiley Blackwell
Number of pages9
ISBN (Print)9781444333664
StatePublished - Mar 21 2011


  • Barker hypothesis - undernourished fetus, exhibiting "thrifty phenotype"
  • DOHaD field, lacking specific mechanisms - for explaining effects for epidemiological observations in adult human disease
  • Developmental origins of health and disease (DOHaD)
  • Fetal amino acids (AA)- from maternal AA pools derived from diet
  • Fetal origins of adult disease/programming
  • IGF family of hormones - modulating growth, cell division and differentiation
  • Maternal undernutrition - and fetal programming, and placental role
  • Multiple factors, interaction - influencing placental delivery of nutrients to fetus
  • Placental transport of AA - affected by activity and location of AA transporter systems
  • Primary determinant of fetal growth - nutrient concentration in maternal circulation

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