Maternal microbiome - A pathway to preterm birth

The Preterm Birth International Collaborative (PREBIC)

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations

Abstract

Despite great medical advances in preventing maternal and infant mortality in the past century, one issue remains unresolved: why do so many women give birth prematurely? A major new field of human microbiome studies has begun to shed light on the impact of microbes (of both the commensal and pathogen varieties) on pregnancy outcomes. Recent advances in next-generation sequencing and metagenomic analysis have revealed that maternal microbiomes at a variety of niches including the oral, vaginal, gut, cervical, and even the placenta itself govern pregnancy outcomes. In this review, we describe how alterations in the microbial biomasses impact preterm birth and we discuss the major research questions concerning the cause and/or interdependent relationships between microbiome, infection, and preterm delivery.

Original languageEnglish
Pages (from-to)94-99
Number of pages6
JournalSeminars in Fetal and Neonatal Medicine
Volume21
Issue number2
DOIs
StatePublished - Apr 1 2016

Keywords

  • Commensal flora
  • Infection
  • Inflammation
  • Metagenomics
  • Microbiome
  • Preterm birth

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