TY - JOUR
T1 - Maternal microbiome - A pathway to preterm birth
AU - The Preterm Birth International Collaborative (PREBIC)
AU - Vinturache, Angela E.
AU - Gyamfi-Bannerman, Cynthia
AU - Hwang, Joseph
AU - Mysorekar, Indira U.
AU - Jacobsson, Bo
N1 - Funding Information:
Dr. Mysorekar is supported by a Preventing Prematurity Initiative grant from the Burroughs Wellcome Fund and a Prematurity Research Initiative Investigator award from the March of Dimes.
Publisher Copyright:
© 2016 Elsevier Ltd.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Despite great medical advances in preventing maternal and infant mortality in the past century, one issue remains unresolved: why do so many women give birth prematurely? A major new field of human microbiome studies has begun to shed light on the impact of microbes (of both the commensal and pathogen varieties) on pregnancy outcomes. Recent advances in next-generation sequencing and metagenomic analysis have revealed that maternal microbiomes at a variety of niches including the oral, vaginal, gut, cervical, and even the placenta itself govern pregnancy outcomes. In this review, we describe how alterations in the microbial biomasses impact preterm birth and we discuss the major research questions concerning the cause and/or interdependent relationships between microbiome, infection, and preterm delivery.
AB - Despite great medical advances in preventing maternal and infant mortality in the past century, one issue remains unresolved: why do so many women give birth prematurely? A major new field of human microbiome studies has begun to shed light on the impact of microbes (of both the commensal and pathogen varieties) on pregnancy outcomes. Recent advances in next-generation sequencing and metagenomic analysis have revealed that maternal microbiomes at a variety of niches including the oral, vaginal, gut, cervical, and even the placenta itself govern pregnancy outcomes. In this review, we describe how alterations in the microbial biomasses impact preterm birth and we discuss the major research questions concerning the cause and/or interdependent relationships between microbiome, infection, and preterm delivery.
KW - Commensal flora
KW - Infection
KW - Inflammation
KW - Metagenomics
KW - Microbiome
KW - Preterm birth
UR - http://www.scopus.com/inward/record.url?scp=84960289118&partnerID=8YFLogxK
U2 - 10.1016/j.siny.2016.02.004
DO - 10.1016/j.siny.2016.02.004
M3 - Review article
C2 - 26936188
AN - SCOPUS:84960289118
VL - 21
SP - 94
EP - 99
JO - Seminars in Fetal and Neonatal Medicine
JF - Seminars in Fetal and Neonatal Medicine
SN - 1744-165X
IS - 2
ER -