Maternal Metabolic Syndrome Programs Mitochondrial Dysfunction via Germline Changes across Three Generations

Jessica L. Saben, Anna L. Boudoures, Zeenat Asghar, Alysha Thompson, Andrea Drury, Wendy Zhang, Maggie Chi, Andrew Cusumano, Suzanne Scheaffer, Kelle H. Moley

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83 Scopus citations

Abstract

Maternal obesity impairs offspring health, but the responsible mechanisms are not fully established. To address this question, we fed female mice a high-fat/high-sugar diet from before conception until weaning and then followed the outcomes in the next three generations of offspring, all fed a control diet. We observed that female offspring born to obese mothers had impaired peripheral insulin signaling that was associated with mitochondrial dysfunction and altered mitochondrial dynamic and complex proteins in skeletal muscle. This mitochondrial phenotype persisted through the female germline and was passed down to the second and third generations. Our results indicate that maternal programming of metabolic disease can be passed through the female germline and that the transfer of aberrant oocyte mitochondria to subsequent generations may contribute to the increased risk for developing insulin resistance.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalCell Reports
Volume16
Issue number1
DOIs
StatePublished - Jun 28 2016

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    Saben, J. L., Boudoures, A. L., Asghar, Z., Thompson, A., Drury, A., Zhang, W., Chi, M., Cusumano, A., Scheaffer, S., & Moley, K. H. (2016). Maternal Metabolic Syndrome Programs Mitochondrial Dysfunction via Germline Changes across Three Generations. Cell Reports, 16(1), 1-8. https://doi.org/10.1016/j.celrep.2016.05.065