Maternal history of hypertension and blood pressure response to potassium intake

Tanika N. Kelly, Dongfeng Gu, D. C. Rao, Jing Chen, Jichun Chen, Jie Cao, Jianxin Li, Fonghong Lu, Jixiang Ma, Jianjun Mu, Paul K. Whelton, Jiang He

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9 Scopus citations


The relation between parental history of hypertension and blood pressure response to potassium intake is unknown. A 7-day high-sodium followed by a 7-day high-sodium plus potassium dietary-feeding study was conducted from 2003 to 2005 among 1,871 Chinese participants. Those with a maternal history of hypertension had larger systolic blood pressure responses to potassium compared with those without:-4.31 (95 confidence interval (CI):-4.99,-3.62) mm Hg versus-3.35 (95 CI:-4.00,-2.70) mm Hg, respectively (Pdifference 0.002). A consistent trend was observed for diastolic blood pressure responses:-1.80 (95 CI:-2.41,-1.20) mm Hg versus-1.35 (95 CI:-1.95,-0.74) mm Hg, respectively (P 0.07). Stronger associations between early onset maternal hypertension and blood pressure responses were noted, with systolic blood pressure decreases of-4.80 (95 CI:-5.65,-3.95) mm Hg versus-3.55 (95 CI:-4.17,-2.93) mm Hg and diastolic blood pressure decreases of-2.25 (95 CI:-3.01,-1.50) mm Hg versus-1.42 (95 CI:-1.99,-0.85) mm Hg among those with early onset maternal hypertension versus those without, respectively (P 0.001 and 0.009, respectively). Odds ratios for high potassium sensitivity were 1.36 (95 CI: 0.96, 1.92) and 1.60 (95 CI: 1.08, 2.36) for those with maternal hypertension and early onset maternal hypertension, respectively (P 0.08 and 0.02, respectively). Potassium supplementation could help to reduce blood pressure among those with a maternal history of hypertension.

Original languageEnglish
Pages (from-to)S55-S63
JournalAmerican journal of epidemiology
Issue numberSUPPL. 7
StatePublished - Oct 1 2012


  • blood pressure
  • dietary potassium
  • family history
  • hypertension


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