Developmental programming of chronic diseases by perinatal exposures/events is the basic tenet of the developmental origins hypothesis of adult disease (DOHaD). With consumption of fructose becoming more common in the diet, the effect of fructose exposure during pregnancy and lactation is of increasing relevance. Human studies have identified a clear effect of fructose consumption on maternal health, but little is known of the direct or indirect effects on offspring. Animal models have been utilized to evaluate this concept and an association between maternal fructose and offspring chronic disease, including hypertension and metabolic syndrome. This review will address the mechanisms of developmental programming by maternal fructose and potential options for intervention.

Original languageEnglish
Article number3278
Issue number9
StatePublished - Sep 2021


  • Developmental origins hypothesis of adult disease (DOHaD)
  • Diabetes
  • Fructose
  • Hypertension
  • Metabolic syndrome
  • Metabolism
  • Obesity
  • Uric acid


Dive into the research topics of 'Maternal fructose diet-induced developmental programming'. Together they form a unique fingerprint.

Cite this