Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2

Valeria Garcia-Flores; Roberto Romero; Yi Xu; Kevin R. Theis; Marcia Arenas-Hernandez; Derek Miller; Azam Peyvandipour; Gaurav Bhatti; Jose Galaz; Meyer Gershater; Dustyn Levenson; Errile Pusod; Li Tao; David Kracht; Violetta Florova; Yaozhu Leng; Kenichiro Motomura; Robert Para; Megan Faucett; Chaur Dong Hsu; Gary Zhang; Adi L. Tarca; Roger Pique-Regi; Nardhy Gomez-Lopez

doi:10.1038/s41467-021-27745-z

Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2

Valeria Garcia-Flores
, Roberto Romero
, Yi Xu
, Kevin R. Theis
, Marcia Arenas-Hernandez
, Derek Miller
, Azam Peyvandipour
, Gaurav Bhatti
, Jose Galaz
, Meyer Gershater
, Dustyn Levenson
, Errile Pusod
, Li Tao
, David Kracht
, Violetta Florova
, Yaozhu Leng
, Kenichiro Motomura
, Robert Para
, Megan Faucett
, Chaur Dong Hsu

Gary Zhang, Adi L. Tarca, Roger Pique-Regi, Nardhy Gomez-Lopez

Research output: Contribution to journal › Article › peer-review

179 Scopus citations

Abstract

Pregnant women represent a high-risk population for severe/critical COVID-19 and mortality. However, the maternal-fetal immune responses initiated by SARS-CoV-2 infection, and whether this virus is detectable in the placenta, are still under investigation. Here we show that SARS-CoV-2 infection during pregnancy primarily induces unique inflammatory responses at the maternal-fetal interface, which are largely governed by maternal T cells and fetal stromal cells. SARS-CoV-2 infection during pregnancy is also associated with humoral and cellular immune responses in the maternal blood, as well as with a mild cytokine response in the neonatal circulation (i.e., umbilical cord blood), without compromising the T-cell repertoire or initiating IgM responses. Importantly, SARS-CoV-2 is not detected in the placental tissues, nor is the sterility of the placenta compromised by maternal viral infection. This study provides insight into the maternal-fetal immune responses triggered by SARS-CoV-2 and emphasizes the rarity of placental infection.

Original language	English
Article number	320
Journal	Nature communications
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/s41467-021-27745-z
State	Published - Dec 2022

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Garcia-Flores, V., Romero, R., Xu, Y., Theis, K. R., Arenas-Hernandez, M., Miller, D., Peyvandipour, A., Bhatti, G., Galaz, J., Gershater, M., Levenson, D., Pusod, E., Tao, L., Kracht, D., Florova, V., Leng, Y., Motomura, K., Para, R., Faucett, M., ... Gomez-Lopez, N. (2022). Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2. Nature communications, 13(1), Article 320. https://doi.org/10.1038/s41467-021-27745-z

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title = "Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2",

abstract = "Pregnant women represent a high-risk population for severe/critical COVID-19 and mortality. However, the maternal-fetal immune responses initiated by SARS-CoV-2 infection, and whether this virus is detectable in the placenta, are still under investigation. Here we show that SARS-CoV-2 infection during pregnancy primarily induces unique inflammatory responses at the maternal-fetal interface, which are largely governed by maternal T cells and fetal stromal cells. SARS-CoV-2 infection during pregnancy is also associated with humoral and cellular immune responses in the maternal blood, as well as with a mild cytokine response in the neonatal circulation (i.e., umbilical cord blood), without compromising the T-cell repertoire or initiating IgM responses. Importantly, SARS-CoV-2 is not detected in the placental tissues, nor is the sterility of the placenta compromised by maternal viral infection. This study provides insight into the maternal-fetal immune responses triggered by SARS-CoV-2 and emphasizes the rarity of placental infection.",

author = "Valeria Garcia-Flores and Roberto Romero and Yi Xu and Theis, \{Kevin R.\} and Marcia Arenas-Hernandez and Derek Miller and Azam Peyvandipour and Gaurav Bhatti and Jose Galaz and Meyer Gershater and Dustyn Levenson and Errile Pusod and Li Tao and David Kracht and Violetta Florova and Yaozhu Leng and Kenichiro Motomura and Robert Para and Megan Faucett and Hsu, \{Chaur Dong\} and Gary Zhang and Tarca, \{Adi L.\} and Roger Pique-Regi and Nardhy Gomez-Lopez",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1038/s41467-021-27745-z",

language = "English",

volume = "13",

journal = "Nature communications",

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Garcia-Flores, V, Romero, R, Xu, Y, Theis, KR, Arenas-Hernandez, M, Miller, D, Peyvandipour, A, Bhatti, G, Galaz, J, Gershater, M, Levenson, D, Pusod, E, Tao, L, Kracht, D, Florova, V, Leng, Y, Motomura, K, Para, R, Faucett, M, Hsu, CD, Zhang, G, Tarca, AL, Pique-Regi, R & Gomez-Lopez, N 2022, 'Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2', Nature communications, vol. 13, no. 1, 320. https://doi.org/10.1038/s41467-021-27745-z

TY - JOUR

T1 - Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2

AU - Garcia-Flores, Valeria

AU - Romero, Roberto

AU - Xu, Yi

AU - Theis, Kevin R.

AU - Arenas-Hernandez, Marcia

AU - Miller, Derek

AU - Peyvandipour, Azam

AU - Bhatti, Gaurav

AU - Galaz, Jose

AU - Gershater, Meyer

AU - Levenson, Dustyn

AU - Pusod, Errile

AU - Tao, Li

AU - Kracht, David

AU - Florova, Violetta

AU - Leng, Yaozhu

AU - Motomura, Kenichiro

AU - Para, Robert

AU - Faucett, Megan

AU - Hsu, Chaur Dong

AU - Zhang, Gary

AU - Tarca, Adi L.

AU - Pique-Regi, Roger

AU - Gomez-Lopez, Nardhy

PY - 2022/12

Y1 - 2022/12

N2 - Pregnant women represent a high-risk population for severe/critical COVID-19 and mortality. However, the maternal-fetal immune responses initiated by SARS-CoV-2 infection, and whether this virus is detectable in the placenta, are still under investigation. Here we show that SARS-CoV-2 infection during pregnancy primarily induces unique inflammatory responses at the maternal-fetal interface, which are largely governed by maternal T cells and fetal stromal cells. SARS-CoV-2 infection during pregnancy is also associated with humoral and cellular immune responses in the maternal blood, as well as with a mild cytokine response in the neonatal circulation (i.e., umbilical cord blood), without compromising the T-cell repertoire or initiating IgM responses. Importantly, SARS-CoV-2 is not detected in the placental tissues, nor is the sterility of the placenta compromised by maternal viral infection. This study provides insight into the maternal-fetal immune responses triggered by SARS-CoV-2 and emphasizes the rarity of placental infection.

AB - Pregnant women represent a high-risk population for severe/critical COVID-19 and mortality. However, the maternal-fetal immune responses initiated by SARS-CoV-2 infection, and whether this virus is detectable in the placenta, are still under investigation. Here we show that SARS-CoV-2 infection during pregnancy primarily induces unique inflammatory responses at the maternal-fetal interface, which are largely governed by maternal T cells and fetal stromal cells. SARS-CoV-2 infection during pregnancy is also associated with humoral and cellular immune responses in the maternal blood, as well as with a mild cytokine response in the neonatal circulation (i.e., umbilical cord blood), without compromising the T-cell repertoire or initiating IgM responses. Importantly, SARS-CoV-2 is not detected in the placental tissues, nor is the sterility of the placenta compromised by maternal viral infection. This study provides insight into the maternal-fetal immune responses triggered by SARS-CoV-2 and emphasizes the rarity of placental infection.

UR - https://www.scopus.com/pages/publications/85123105603

U2 - 10.1038/s41467-021-27745-z

DO - 10.1038/s41467-021-27745-z

M3 - Article

C2 - 35042863

AN - SCOPUS:85123105603

SN - 2041-1723

VL - 13

JO - Nature communications

JF - Nature communications

IS - 1

M1 - 320

ER -

Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2

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