TY - JOUR
T1 - Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2
AU - Garcia-Flores, Valeria
AU - Romero, Roberto
AU - Xu, Yi
AU - Theis, Kevin R.
AU - Arenas-Hernandez, Marcia
AU - Miller, Derek
AU - Peyvandipour, Azam
AU - Bhatti, Gaurav
AU - Galaz, Jose
AU - Gershater, Meyer
AU - Levenson, Dustyn
AU - Pusod, Errile
AU - Tao, Li
AU - Kracht, David
AU - Florova, Violetta
AU - Leng, Yaozhu
AU - Motomura, Kenichiro
AU - Para, Robert
AU - Faucett, Megan
AU - Hsu, Chaur Dong
AU - Zhang, Gary
AU - Tarca, Adi L.
AU - Pique-Regi, Roger
AU - Gomez-Lopez, Nardhy
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Pregnant women represent a high-risk population for severe/critical COVID-19 and mortality. However, the maternal-fetal immune responses initiated by SARS-CoV-2 infection, and whether this virus is detectable in the placenta, are still under investigation. Here we show that SARS-CoV-2 infection during pregnancy primarily induces unique inflammatory responses at the maternal-fetal interface, which are largely governed by maternal T cells and fetal stromal cells. SARS-CoV-2 infection during pregnancy is also associated with humoral and cellular immune responses in the maternal blood, as well as with a mild cytokine response in the neonatal circulation (i.e., umbilical cord blood), without compromising the T-cell repertoire or initiating IgM responses. Importantly, SARS-CoV-2 is not detected in the placental tissues, nor is the sterility of the placenta compromised by maternal viral infection. This study provides insight into the maternal-fetal immune responses triggered by SARS-CoV-2 and emphasizes the rarity of placental infection.
AB - Pregnant women represent a high-risk population for severe/critical COVID-19 and mortality. However, the maternal-fetal immune responses initiated by SARS-CoV-2 infection, and whether this virus is detectable in the placenta, are still under investigation. Here we show that SARS-CoV-2 infection during pregnancy primarily induces unique inflammatory responses at the maternal-fetal interface, which are largely governed by maternal T cells and fetal stromal cells. SARS-CoV-2 infection during pregnancy is also associated with humoral and cellular immune responses in the maternal blood, as well as with a mild cytokine response in the neonatal circulation (i.e., umbilical cord blood), without compromising the T-cell repertoire or initiating IgM responses. Importantly, SARS-CoV-2 is not detected in the placental tissues, nor is the sterility of the placenta compromised by maternal viral infection. This study provides insight into the maternal-fetal immune responses triggered by SARS-CoV-2 and emphasizes the rarity of placental infection.
UR - http://www.scopus.com/inward/record.url?scp=85123105603&partnerID=8YFLogxK
U2 - 10.1038/s41467-021-27745-z
DO - 10.1038/s41467-021-27745-z
M3 - Article
C2 - 35042863
AN - SCOPUS:85123105603
SN - 2041-1723
VL - 13
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 320
ER -