TY - JOUR
T1 - Maternal exposure to di-2-ethylhexylphthalate and adverse delivery outcomes
T2 - A systematic review
AU - Yaghjyan, Lusine
AU - Ghita, Gabriela L.
AU - Dumont-Driscoll, Marilyn
AU - Yost, Richard A.
AU - Chang, Su Hsin
N1 - Funding Information:
This work was supported by the Agency for Healthcare Research and Quality ( K01 HS022330 to S-H.C.); the Foundation for Barnes-Jewish Hospital ; and the National Institutes of Health ( U54 CA155496 to S-H.C.).
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Adverse pregnancy outcomes, including preterm delivery, short gestational age, and abnormal birth weight, remain a public health concern. The evidence on the association of the most common phthalate, di-2-ethylhexyl phthalate (DEHP) with adverse pregnancy outcomes remains equivocal. This systematic review summarizes published studies that investigated the association of DEHP with preterm delivery, gestational age, and birthweight. A comprehensive literature search found 15 relevant studies, most of which evaluated more than one outcome (four studies for preterm delivery, nine studies for gestational age, and ten studies for birthweight). Studies varied greatly with respect to study design, exposure assessment, analytical methods, and direction of the associations. We identified important methodological concerns which could have resulted in selection bias and exposure misclassification and contributed to null findings and biased associations. Given limitations of the previous studies discussed in this review, more thorough investigation of these associations is warranted to advance our scientific knowledge.
AB - Adverse pregnancy outcomes, including preterm delivery, short gestational age, and abnormal birth weight, remain a public health concern. The evidence on the association of the most common phthalate, di-2-ethylhexyl phthalate (DEHP) with adverse pregnancy outcomes remains equivocal. This systematic review summarizes published studies that investigated the association of DEHP with preterm delivery, gestational age, and birthweight. A comprehensive literature search found 15 relevant studies, most of which evaluated more than one outcome (four studies for preterm delivery, nine studies for gestational age, and ten studies for birthweight). Studies varied greatly with respect to study design, exposure assessment, analytical methods, and direction of the associations. We identified important methodological concerns which could have resulted in selection bias and exposure misclassification and contributed to null findings and biased associations. Given limitations of the previous studies discussed in this review, more thorough investigation of these associations is warranted to advance our scientific knowledge.
KW - Birthweight
KW - Gestational age
KW - Phthalate exposure
KW - Preterm delivery
UR - http://www.scopus.com/inward/record.url?scp=84978886185&partnerID=8YFLogxK
U2 - 10.1016/j.reprotox.2016.07.002
DO - 10.1016/j.reprotox.2016.07.002
M3 - Review article
C2 - 27412369
AN - SCOPUS:84978886185
SN - 0890-6238
VL - 65
SP - 76
EP - 86
JO - Reproductive Toxicology
JF - Reproductive Toxicology
ER -