Maternal diabetes and oocyte quality

Qiang Wang, Kelle H. Moley

Research output: Contribution to journalReview article

49 Scopus citations

Abstract

Maternal diabetes has been demonstrated to adversely affect preimplantation embryo development and pregnancy outcomes. Emerging evidence has implicated that these effects are associated with compromised oocyte competence. Several developmental defects during oocyte maturation in diabetic mice have been reported over past decades. Most recently, we further identified the structural, spatial and metabolic dysfunction of mitochondria in oocytes from diabetic mice, suggesting the impaired oocyte quality. These defects in the oocyte may be maternally transmitted to the embryo and then manifested later as developmental abnormalities in preimplantation embryo, congenital malformations, and even metabolic disease in the offspring. In this paper, we briefly review the effects of maternal diabetes on oocyte quality, with a particular emphasis on the mitochondrial dysfunction. The possible connection between dysfunctional oocyte mitochondria and reproductive failure of diabetic females, and the mechanism(s) by which maternal diabetes exerts its effects on the oocyte are also discussed.

Original languageEnglish
Pages (from-to)403-410
Number of pages8
JournalMitochondrion
Volume10
Issue number5
DOIs
StatePublished - Aug 1 2010

Keywords

  • Diabetes
  • Embryo
  • Mitochondria
  • Mouse
  • Oocyte quality

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