Maternal circulating concentrations of soluble Fas and Elabela in early- and late-onset preeclampsia

Robert Para, Roberto Romero, Nardhy Gomez-Lopez, Adi L. Tarca, Bogdan Panaitescu, Bogdan Done, Richard Hsu, Percy Pacora, Chaur Dong Hsu

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Objective: The Fas/Fas ligand (FASL) system and Elabela-apelin receptor signaling pathways are implicated in the pathophysiology of preeclampsia. The aim of the current study was to investigate whether a model combining the measurement of sFas and Elabela in the maternal circulation may serve as a clinical biomarker for early- and/or late-onset preeclampsia more effectively than measures of each biomarker individually. Methods: Blood samples were collected from 214 women in the following groups: (1) normal pregnancy sampled <34 weeks of gestation (n = 56); (2) patients who developed early-onset preeclampsia (n = 54); (3) normal pregnancy sampled ≥34 weeks of gestation (n = 52); (4) patients who developed late-onset preeclampsia (n = 52). Maternal circulating soluble Fas and Elabela concentrations were determined using sensitive and validated immunoassays. Two sample t-tests, multivariate logistic regression, and receiver operating characteristic curves were used for analyses. Results: (1) Women with early-onset preeclampsia, and those with late-onset preeclampsia with placental lesions of maternal vascular malperfusion, had increased concentrations of sFas compared to their gestational age-matched normal controls; (2) women with late-onset preeclampsia, but not those with early-onset preeclampsia, had increased concentrations of Elabela compared to their gestational age-matched counterparts; and (3) an increase in both Elabela and sFas concentrations was more strongly associated with late-onset preeclampsia than early-onset preeclampsia relative to models including either of the markers alone. Conclusions: A combined model of maternal sFas and Elabela concentrations provides a stronger association with late-onset preeclampsia than either protein alone. This finding demonstrates the possibility to improve the classification of late-onset preeclampsia by combining the results of both molecular biomarkers.

Original languageEnglish
Pages (from-to)316-329
Number of pages14
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number2
StatePublished - 2022


  • Apela
  • biomarker
  • maternal vascular underperfusion
  • placenta lesions
  • pregnancy
  • preterm delivery


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