Maternal and neonatal levels of perfluoroalkyl substances in relation to gestational weight gain

Jillian Ashley-Martin, Linda Dodds, Tye E. Arbuckle, Anne Sophie Morisset, Mandy Fisher, Maryse F. Bouchard, Gabriel D. Shapiro, Adrienne S. Ettinger, Patricia Monnier, Renee Dallaire, Shayne Taback, William Fraser

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26 Scopus citations


Perfluoroalkyl substances (PFASs) are ubiquitous, persistent pollutants widely used in the production of common household and consumer goods. There is a limited body of literature suggesting that these chemicals may alter metabolic pathways and growth trajectories. The relationship between prenatal exposures to these chemicals and gestational weight gain (GWG) has received limited attention. One objective was to analyze the associations among maternal plasma levels of three common perfluoroalkyl substances (perfluorooctanoate (PFOA), perfluorooctanesulfonate (PFOS), perfluorohexanesulfanoate (PFHxS)) and GWG. Additionally, we explored whetherGWGwas associated with cord blood PFAS levels. This study utilized data collected in the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a trans-Canada cohort study of 2001 pregnant women. Our analysis quantified associations between (1) maternal PFAS concentrations and GWG and (2) GWG and cord blood PFAS concentrations. Maternal PFOS concentrations were positively associated with GWG (b = 0.39 95% CI: 0.02, 0.75). Interquartile increases in GWG were significantly associated with elevated cord blood PFOA (OR = 1.33; 95% CI: 1.13 to 1.56) and PFOS (OR = 1.20; 95% CI: 1.03 to 1.40) concentrations. No statistically significant associations were observed between GWG and either measure of PFHxS. These findings warrant elucidation of the potential underlying mechanisms.

Original languageEnglish
JournalInternational journal of environmental research and public health
Issue number1
StatePublished - Jan 20 2016
Externally publishedYes


  • Birth cohort
  • Environmental contaminants
  • Gestational weight gain
  • Perfluoroalkyl substances


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