TY - JOUR
T1 - Maternal and neonatal levels of perfluoroalkyl substances in relation to gestational weight gain
AU - Ashley-Martin, Jillian
AU - Dodds, Linda
AU - Arbuckle, Tye E.
AU - Morisset, Anne Sophie
AU - Fisher, Mandy
AU - Bouchard, Maryse F.
AU - Shapiro, Gabriel D.
AU - Ettinger, Adrienne S.
AU - Monnier, Patricia
AU - Dallaire, Renee
AU - Taback, Shayne
AU - Fraser, William
N1 - Funding Information:
We would like to acknowledge the MIREC Study Group as well as the MIREC study participants and staff. This study was funded by a grant from the Canadian Diabetes Association (OG-2-1-3424-LD). The MIREC Study was funded by the Chemicals Management Plan of Health Canada, the Canadian Institutes for Health Research (MOP-81285), and the Ontario Ministry of the Environment.
Publisher Copyright:
© 2016 by the authors; licensee MDPI, Basel, Switzerland.
PY - 2016/1/20
Y1 - 2016/1/20
N2 - Perfluoroalkyl substances (PFASs) are ubiquitous, persistent pollutants widely used in the production of common household and consumer goods. There is a limited body of literature suggesting that these chemicals may alter metabolic pathways and growth trajectories. The relationship between prenatal exposures to these chemicals and gestational weight gain (GWG) has received limited attention. One objective was to analyze the associations among maternal plasma levels of three common perfluoroalkyl substances (perfluorooctanoate (PFOA), perfluorooctanesulfonate (PFOS), perfluorohexanesulfanoate (PFHxS)) and GWG. Additionally, we explored whetherGWGwas associated with cord blood PFAS levels. This study utilized data collected in the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a trans-Canada cohort study of 2001 pregnant women. Our analysis quantified associations between (1) maternal PFAS concentrations and GWG and (2) GWG and cord blood PFAS concentrations. Maternal PFOS concentrations were positively associated with GWG (b = 0.39 95% CI: 0.02, 0.75). Interquartile increases in GWG were significantly associated with elevated cord blood PFOA (OR = 1.33; 95% CI: 1.13 to 1.56) and PFOS (OR = 1.20; 95% CI: 1.03 to 1.40) concentrations. No statistically significant associations were observed between GWG and either measure of PFHxS. These findings warrant elucidation of the potential underlying mechanisms.
AB - Perfluoroalkyl substances (PFASs) are ubiquitous, persistent pollutants widely used in the production of common household and consumer goods. There is a limited body of literature suggesting that these chemicals may alter metabolic pathways and growth trajectories. The relationship between prenatal exposures to these chemicals and gestational weight gain (GWG) has received limited attention. One objective was to analyze the associations among maternal plasma levels of three common perfluoroalkyl substances (perfluorooctanoate (PFOA), perfluorooctanesulfonate (PFOS), perfluorohexanesulfanoate (PFHxS)) and GWG. Additionally, we explored whetherGWGwas associated with cord blood PFAS levels. This study utilized data collected in the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a trans-Canada cohort study of 2001 pregnant women. Our analysis quantified associations between (1) maternal PFAS concentrations and GWG and (2) GWG and cord blood PFAS concentrations. Maternal PFOS concentrations were positively associated with GWG (b = 0.39 95% CI: 0.02, 0.75). Interquartile increases in GWG were significantly associated with elevated cord blood PFOA (OR = 1.33; 95% CI: 1.13 to 1.56) and PFOS (OR = 1.20; 95% CI: 1.03 to 1.40) concentrations. No statistically significant associations were observed between GWG and either measure of PFHxS. These findings warrant elucidation of the potential underlying mechanisms.
KW - Birth cohort
KW - Environmental contaminants
KW - Gestational weight gain
KW - Perfluoroalkyl substances
UR - http://www.scopus.com/inward/record.url?scp=84955137583&partnerID=8YFLogxK
U2 - 10.3390/ijerph13010146
DO - 10.3390/ijerph13010146
M3 - Article
C2 - 26805861
AN - SCOPUS:84955137583
SN - 1661-7827
VL - 13
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
IS - 1
ER -