Materials, Mechanics Designs, and Bioresorbable Multisensor Platforms for Pressure Monitoring in the Intracranial Space

Quansan Yang, Seungae Lee, Yeguang Xue, Ying Yan, Tzu Li Liu, Seung Kyun Kang, Yung Jong Lee, Seok Hwan Lee, Min Ho Seo, Di Lu, Jahyun Koo, Matthew R. MacEwan, Rose T. Yin, Wilson Z. Ray, Yonggang Huang, John A. Rogers

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Pressures in the intracranial, intraocular, and intravascular spaces are important parameters in assessing patients with a range of conditions, of particular relevance to those recovering from injuries or from surgical procedures. Compared with conventional devices, sensors that disappear by natural processes of bioresorption offer advantages in this context, by eliminating the costs and risks associated with retrieval. A class of bioresorbable pressure sensor that is capable of operational lifetimes as long as several weeks and physical lifetimes as short as several months, as combined metrics that represent improvements over recently reported alternatives, is presented. Key advances include the use of 1) membranes of monocrystalline silicon and blends of natural wax materials to encapsulate the devices across their top surfaces and perimeter edge regions, respectively, 2) mechanical architectures to yield stable operation as the encapsulation materials dissolve and disappear, and 3) additional sensors to detect the onset of penetration of biofluids into the active sensing areas. Studies that involve monitoring of intracranial pressures in rat models over periods of up to 3 weeks demonstrate levels of performance that match those of nonresorbable clinical standards. Many of the concepts reported here have broad applicability to other classes of bioresorbable technologies.

Original languageEnglish
Article number1910718
JournalAdvanced Functional Materials
Issue number17
StatePublished - Apr 1 2020


  • bioabsorbable electronics
  • biomedical implants
  • pressure sensors
  • transient electronics


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